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TranscriptomicsTranscription profiling of human DLD-1 cells stably expressing FOXO3a.A3-ER
In order to elucidate how FOXOs affect diverse cellular processes such as cell cycle progression, stress response and transformation we made use of an inducible version of the FOXO3a protein fused to the hormone binding domain of the human estrogen receptor (FOXO3a-A3-ER) in which all three Akt phos...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-MEXP-721 | biostudies-arrayexpress
MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
GenomicsFOXO3 regulates gene expression from distal enhancers
FOXO transcription factors are key players in diverse cellular responses affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into mechanisms of FOXO regulated gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II (RNAPII) changes sh...
ORGANISM(S): Homo sapiens 
2012-12-30 | E-GEOD-36835 | biostudies-arrayexpress
GenomicsGenome wide analysis of FOXO3 transcription regulation through RNA pol II profiling
FOXO transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into mechanisms of FOXO regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes show...
ORGANISM(S): Homo sapiens 
2012-11-15 | E-GEOD-35486 | biostudies-arrayexpress
UnknownLRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Not available
S-SCDT-10_15252-EMMM_202318014 | biostudies-other
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