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GenomicsA CRISPR knockout screen revealed modulators of Chlamydia trachomatis parasitophorous vacuole stability
Chlamydia trachomatis is a prevalent bacterial cause of urogenital and ocular infections. The pathogen uses the effector CpoS to suppress a host defense response that aborts intracellular bacterial growth by inducing host cell death. We conducted a CRISPR knockout screen to identify host genes contr...
ORGANISM(S): Homo sapiens 
2025-07-10 | E-MTAB-15337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type or Ercc1 mutant mice
The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To ...
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
UnknownGenetic determinants of telomere length and risk of common cancers: a Mendelian randomization study.
Not available
S-EPMC4550826 | biostudies-literature
UnknownAssociation between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
Not available
S-EPMC10844944 | biostudies-literature
Unknown2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.
Not available
S-EPMC4082638 | biostudies-literature
UnknownA large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.
Not available
S-EPMC3943524 | biostudies-literature
UnknownCommon non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Not available
S-EPMC4204770 | biostudies-literature
UnknownGenetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Not available
S-EPMC4204763 | biostudies-literature
UnknownGenetic predisposition to in situ and invasive lobular carcinoma of the breast.
Not available
S-EPMC3990493 | biostudies-literature
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