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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
UnknownFluorometric In Situ Monitoring of an Escherichia coli Cell Factory with Cytosolic Expression of Human Glycosyltransferase GalNAcT2: Prospects and Limitations.
Not available
S-EPMC5597275 | biostudies-literature
TranscriptomicsMetformin mild supplementation improves health and survival of mice
Metformin, a commonly used drug prescribed to treat type-2 diabetes, has been found to extend health span and delay cancer incidence and progression. Here, we report that starting chronic treatment with low dose of metformin (0.1% w/w in diet) at one year of age extends health and lifespan in male m...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-40936 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
ProteomicsTranscriptome and proteome profiles of the diazotroph Nitrospirillum amazonense strain CBAmC in response to the sugarcane apoplast fluid
The diazotrophic CBAmC strain of Nitrospirillum amazonense has been reported to promote growth of sugarcane variety RB867515 when inoculated under field conditions in a consortium with four other nitrogen-fixing bacteria. The present work had the objective of accessing the influence of the sugarcane...
ORGANISM(S): Nitrospirillum amazonense CBAmc 
2019-07-12 | PXD013518 | Pride
Transcripts  proteins  bacteria-plant interaction  saccharum spp. 
UnknownStructural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone.
Not available
S-EPMC3675614 | biostudies-literature
UnknownReproductive Health Experiences Shared on TikTok by Young People: Content Analysis.
Not available
S-EPMC10682920 | biostudies-literature
UnknownEvolution and functional divergence of glycosyltransferase genes shaped the quality and cold tolerance of tea plants.
Not available
S-EPMC11663605 | biostudies-literature
UnknownMetformin improves healthspan and lifespan in mice.
Not available
S-EPMC3736576 | biostudies-literature
UnknownExploring the feasibility and acceptability of community paramedicine programs in achieving vaccination equity: a qualitative study.
Not available
S-EPMC11375945 | biostudies-literature
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