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ProteomicsIdentification of C6-ceramide-interacting proteins in D6P2T Schwannoma cells.
In this study, we have utilized affinity purification with a synthetic biotin-ceramide and LC-MS/MS to identify potential ceramide-interacting proteins in D6P2T Schwannoma cells.
ORGANISM(S): Rattus rattus (Black rat) 
2015-09-07 | PRD000566 | Pride
ProteomicsShotgun mass-spectrometry of cerebrospinal fluid (liquor) obtained from patients with vestibular schwannoma
Cerebrospinal fluid (liquor) samples (N = 44) have been derived from patients with vestibular schwannoma that comprises about 10% of all intracranial tumors. Applying high resolution tandem mass-spectrometry 525 proteins were identified with high confidence (at least 2 peptides per protein, FDR <1%)...
ORGANISM(S): Homo sapiens (Human) 
2025-01-16 | PXD037746 | Pride
Human Cerebrospinal fluid Proteomics Hypoglossal schwannoma High-resolution mass-spectrometry 
ProteomicsEpigenetic reprogramming shapes the cellular landscape of schwannoma
Cell state evolution underlies tumor development and response to therapy1, but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the peripheral nervous system and are treated with surgery and ionizing radiatio...
ORGANISM(S): Homo sapiens (Human) 
2023-04-18 | PXD014798 | Pride
Human Cancer Lumos Maxquant 
TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
Methylation profilingGenomic Landscape of Schwannoma
Epigenome analysis of schwannoma tumor samples
ORGANISM(S): Homo sapiens 
2016-10-10 | GSE79009 | GEO
TranscriptomicsMicroarray Analysis in Vestibular Schwannomas
Vestibular Schwannomas are benign neoplasms that arise from the vestibular nerve. The hallmark of these tumors is the biallelic inactivation of NF2. Transcriptomic alterations, such as the Nrg1/ErbB2 pathway, have been described in Schwannomas. Here, we have performed a whole transcriptomic analysis...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-39645 | biostudies-arrayexpress
GenomicsEpigenetic reprogramming shapes the cellular landscape of schwannoma, DNA Methylation
Epigenetic reprogramming shapes the cellular landscape of schwannoma, DNA Methylation
PRJNA917427 | ENA
GenomicsTumor heterogeneity in schwannoma
Tumor heterogeneity in schwannoma
PRJNA1530417 | ENA
GenomicsTumor heterogeneity in schwannoma
Tumor heterogeneity in schwannoma
PRJNA1530418 | ENA
TranscriptomicsmicroRNA profiles of schwannomas
MicroRNAs (miRNAs) negatively regulate protein-coding genes at the post-transcriptional level and are critical in tumorigenesis. Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap around nerve fibers to help support and insulate nerves. In this study, we ca...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-24390 | biostudies-arrayexpress
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