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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
UnknownAdipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells.
Not available
S-EPMC7280538 | biostudies-literature
ProteomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The transcriptome, proteome and metabolome of 16 S.cerevisiae backgrounds, combinatorially perturbed in HIS3, LEU2, URA3 and MET15strains are compared. The project was jointly supervised by Kathryn Lilley and Markus Ralser. Transcriptome data has been deposited at ArrayExpress under accession
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-01-05 | PXD001491 | Pride
S. cerevisiae 
ProteomicsT cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells
Immunopeptidome analysis of patient-derived colorectal cancer cell lines HROC113 and HROC285 T0 M2 from the HROC collection [Mullins et al. Cancers (Basel). 2019;11(10):1520. doi: 10.3390/cancers11101520] was performed to characterize the natural HLA class I presented ligandome in native as well as ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037587 | Pride
Hla-presented peptides  neoepitope Colorectal cancer Human Hla class i Antigen presentation Lc-msms 
ProteomicsChemical Crosslinking of Isotopically Labeled α-Synuclein Reveals Structural Changes and the Interface of Oligomeric Species
Due to its high pharmaceutical relevance, α-synuclein is one of the best studied intrinsically disordered proteins to date. Its structural plasticity reaches from α-helical when bound to membranes through disordered in solution to β-sheet when forming amyloid fibrils. Recently the possible toxicity ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD027349 | Pride
Human Cross-linking mass spectrometry Α-synuclein 
ProteomicsExtracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells. In the central nervous system, EVs have been linked to many...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD062783 | Pride
Hippocampus Synaptic activity Nmda receptor Extracellular vesicles Cortex 
UnknownThe genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Not available
S-EPMC5042863 | biostudies-literature
UnknownPrognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial.
Not available
S-EPMC11825916 | biostudies-literature
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