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TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-09 | E-GEOD-34729 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-39103 | biostudies-arrayexpress
TranscriptomicsmRNA Profiling of Polysome fractions from #483 T-ALL treated with 4EGI-1 or DMSO
High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukemia (T-ALL). Here we investigated how 4EGI-1, a small inhibitor of cap-dependent translation, induces apoptosis in T-ALL clones displaying hyperactive PI3K-AKT-mTOR signaling. 4EGI-1 treatment reduce...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-41382 | biostudies-arrayexpress
TranscriptomicsmRNA Profiling of cytoplasmic and polysome fractions from #483 T-ALL treated with 4EGI-1 or DMSO
High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukemia (T-ALL). Here we investigated how 4EGI-1, a small inhibitor of cap-dependent translation, induces apoptosis in T-ALL clones displaying hyperactive PI3K-AKT-mTOR signaling. 4EGI-1 treatment reduce...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-56150 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of #483 T-ALL clone FACS sorted from BM and spleen
#483 T-ALL cells were transplanted into C57BL6/J mice. Engraftment was monitored by FACS analysis of peripheral blood obtained by retroorbital blood collection. 20 days after transplantation EGFP+ T-ALL cells were sorted from the bone marrow and spleen of three individual mice. Total RNA was prepare...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-41385 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by Evi1 withdrawal in Evi1 dependent myeloid clone C6
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-34755 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-39104 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of MN1 and MN1VP16 in murine bone marrow cells
Myeloid differentiation is blocked in acute myeloid leukemia (AML), but the molecular mechanisms are not well characterized. MN1 is overexpressed in some AML patients and confers resistance to all-trans retinoic acid (ATRA)-induced differentiation. To understand the role of MN1 as a transcriptional ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-48819 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by expression of dMPL in murine bone haematopoietic progenitor cells
Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hematological disorders. Here, we constructed an intrac...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-69209 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by expression of MN1 deletion mutants in murine bone marrow cells
Extensive molecular profiling of leukemias and preleukemic diseases has revealed that distinct clinical entities, like acute myeloid (AML) and T-lymphoblastic leukemia, share the same pathogenetic mutations. It is not well understood how the cell of origin, accompanying mutations, extracellular sign...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-46990 | biostudies-arrayexpress
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