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TranscriptomicsGene expression profiling of mouse liver cells
We generated the individual transcriptomes of 96 liver cells using the Fluidigm C1 platform. In brief, a suspension of cells was prepared from the liver of a 14-week old B6CastF1 (C57Bl/6J mother x CAST/Ei father) female mouse and loaded onto a 10-17 m C1 Single-Cell Auto Prep IFC (Fluidigm), and ce...
ORGANISM(S): Mus musculus 
2016-02-08 | E-MTAB-3707 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of blastomeres from 2- to 32-cell stage mouse embryos
Transcriptomes were determined for all blastomeres of 28 embryos at the 2- (n=8), 4- (n=16) and 8-cell (n=4) stages, and for individual cells taken from 16- (n=6) and 32- (n=6) cell stage embryos. We also carefully monitored the 2- to 4-cell divisions noting whether the cleavage plane was meridional...
ORGANISM(S): Mus musculus 
2016-03-23 | E-MTAB-3321 | biostudies-arrayexpress
TranscriptomicsRNA-seq of epiblast from mouse embryos at E4.5, E4.75 and E5.0
In order to gain a global temporal picture of epiblast potency across implantation, we collected mouse embryos at E4.5, E4.75 and E5.0, and dissected the epiblast for deep-sequencing analysis.
ORGANISM(S): Mus musculus 
2017-11-24 | E-MTAB-5147 | biostudies-arrayexpress
TranscriptomicsInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
B cells from anonymous adenoid donors were isolated and sorted for naïve B cells, which were subsequently infected with a reference EBV strain (2089_B95-8) using a defined multiplicity of infection. Infection of resting B cells with EBV induces their activation, their proliferation, and subsequent i...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7805 | biostudies-arrayexpress
TranscriptomicsTOMO-seq along lateral axis, dorsal-ventral axis and anterior-posterior axis of mouse main olfactory epithelium
We use a spatial transcriptomic technique (TOMO-seq) to build a 3D map of gene expression patterns in the mouse olfactory mucosa, which can be used to start addressing many unanswered questions, about olfaction and the importance of gene expression zones in the olfactory mucosa related to it, and al...
ORGANISM(S): Mus musculus 
2022-02-17 | E-MTAB-10211 | biostudies-arrayexpress
TranscriptomicsRNA-seq of two hybrid mouse embryonic stem cell lines in a competitive environment during pluripotency: comparison between separate and co-culture conditions
Compared two hybrid mouse embryonic stem cell lines (that contain the same nuclear background, but different mtDNA content) in separate and co-culture conditions. We investigated the genes differentially expressed between these two cell lines in separate and co-culture as well as the genes that chan...
ORGANISM(S): Mus musculus 
2020-01-18 | E-MTAB-8692 | biostudies-arrayexpress
GenomicsSingle Cell Expression Profiling Resolves the Transcriptional Programs of Early Mesoderm Diversification
We analyzed 1,205 cells from the epiblast and nascent mesoderm of gastrulating mouse embryos by single cell RNA-seq, representing the first transcriptome-wide in vivo view of mammalian gastrulation. Based on the distribution of key marker genes and their spatiotemporal expression patterns within the...
ORGANISM(S): Mus musculus 
2016-07-07 | E-GEOD-74994 | biostudies-arrayexpress
TranscriptomicsMyeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Tissue stem cells are hierarchically organized, but the signals that selectively preserve their functional integrity are largely unknown. Semaphorin 4A (Sema4A) is a specific regulator of myeloid-biased hematopoietic stem cells (myHSC), which are positioned at the top of the HSC hierarchy. Through s...
ORGANISM(S): Mus musculus 
2023-06-04 | E-MTAB-12890 | biostudies-arrayexpress
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