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UnknownPhase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.
Not available
S-EPMC4881374 | biostudies-literature
GenomicsInduction of sarcomas by mutant IDH2
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation ...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-50539 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
ProteomicsComplement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
Critical illness is characterised by organ failure, dysregulated immune activation and frequent secondary infections. Unbridled complement activation in these patients exposes immune cells to high levels of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of key immune cells, in partic...
ORGANISM(S): Homo sapiens (Human) 
2020-08-06 | PXD017092 | Pride
Critical care Neutrophils Staphylococcus aureus Complement system proteins Phosphoproteome 
GenomicsGenomewide Association Study of Alcohol Use and Alcohol Use Disorder in Australian Twin-Families (OZ-ALC GWAS)

The Australian twin-family study of alcohol use disorder (OZALC study) derives from telephone diagnostic interview studies of two general population volunteer cohorts of Australian twins (cohort 1, mostly born 1940-1964; cohort 2, born 1964-71) and the spouses of the former cohort - a total of ov...

phs000181.v1.p1 | EGA
GenomicsUQ Data Access Commitee
Data Access Committee EGAC00001002686
EGAC00001002686 | EGA
GenomicsPCGP OS WGS - samples
DATA FILES FOR SJOS-WGS-2ndBatch
EGAD00001001053 | EGA
GenomicsPCGP OS - samples
DATA FILES FOR SJOS
EGAD00001000159 | EGA
GenomicsPCGP OS RNASEQ - samples
RNA-Seq files for SJOS study
EGAD00001003154 | EGA
GenomicsGenetic landscape of pediatric Osteosarcoma
We performed whole-genome sequencing of 37 paired tumor/normal OS genomes and analyzed somatically acquired single nucleotide variations (SNVs), insertion/deletions, structural variations and copy number variations in the cancer genomes
EGAS00001000263 | EGA
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