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TranscriptomicsExpression data from WT and Aire deficient mTECs
Aire is an important transcription regulator that mediates a role in central tolerance via promoting the promiscuous expression of tissue-specific antigens in the thymus. Although several mouse models of Aire-deficiency have been described, none has analysed the phenotype induced by a mutation that ...
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-14365 | biostudies-arrayexpress
TranscriptomicsProfiling of spatio-temporally regulated transcripts during cerebral corticogenesis in the mouse
The cerebral cortex plays an important role in cognitive function and specialized perception in mammals and its development requires highly specific spatio-temporal control of gene expression. The study identified stage- and region-specific markers throughout cerebral corticogenesis at various impor...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-15031 | biostudies-arrayexpress
TranscriptomicsDeep sequencing analysis of the developing mouse brain reveals a novel microRNA
MicroRNAs (miRNAs) are small non-coding RNAs that can exert multilevel inhibition/repression at a post-transcriptional or protein synthesis level during disease or development. Characterisation of miRNAs in adult mammalian brains by deep sequencing has been reported previously. However, to date, no ...
ORGANISM(S): Mus musculus 
2011-04-04 | E-GEOD-22653 | biostudies-arrayexpress
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
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