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MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
MetabolomicsMetabolic signatures of Arabidopsis thaliana abiotic stress responses elucidate patterns in stress priming, acclimation, and recovery

Temperature, water and light are 3 abiotic stress factors that have major influences on plant growth, development and reproduction. Plants can be primed by a prior mild stress to enhance their resistance to future stress. We used an untargeted metabolomics approach to examine Arabidopsis thal...

2022-05-30 | MTBLS3672 | MetaboLights
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
MetabolomicsIdentification of Metabolites and Transcripts Involved in Salt Stress and Recovery in Peanut
Peanut (Arachis hypogaea L.) is considered as a moderately salt-sensitive species and thus soil salinity can be a limiting factor for peanut cultivation. To gain insights into peanut plant physiology in response to salt stress and alleviation, we comprehensively characterized leaf relative electroly...
2019-03-19 | MTBLS583 | MetaboLights
TranscriptomicsSecretion stress caused by overexpression of heterologous α-amylase in Bacillus subtilis
Transcriptome analysis was used to investigate the global stress response of the Gram-positive bacterium Bacillus subtilis caused by overproduction of the well-secreted AmyQ α-amylase from Bacillus amyloliquefaciens. Analyses of the control and overproducing strains were carried out at the end of ex...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2007-10-01 | E-GEOD-8014 | biostudies-arrayexpress
MetabolomicsModulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage

Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aim to explore the preventive effect of AH on liver damage induced by heat stress (HS) and its underlying mechanism. HS models were established by thermostat, and mice ...

2024-09-23 | MTBLS10021 | MetaboLights
MetabolomicsMetabolism links nutrient stress and harmful algal bloom formation

Four species of phytoplankton representing important bloom-forming species from three globally important phyla (Bacillariophyta, Haptophyta, and Ochrophyte) were cultured in this study. These species include the cosmopolitan diatom Chaetoceros affinis CCMP159 (isolated from Great South B...

2024-02-28 | MTBLS1807 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15629 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15630 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
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