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MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsA molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (S...
2024-01-24 | MTBLS1991 | MetaboLights
ProteomicsHigh throughput generation of a resource of the human secretome in mammalian cells
The proteins secreted by human tissues (the secretome) are important for the basic understanding of human biology, but also for identification of potential targets for future diagnosis and therapy. Here, we present an annotation of all predicted secreted proteins (n=2,623) with information about the...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD012054 | panorama
ProteomicsA genetic model for in vivo proximity labeling of the mammalian secretome
Yang R, Meyer AS, Droujinine I, Udeshi ND, Hu Y, Guo J, McMahon J, Carey DK, Xu C, Qiao F, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP. 2022. Organ functions are highly specialized and interdependent. Tissue-specific secreted factors play a critical role in organ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-16 | MSV000088848 | MassIVE
ProteomicsProteomic analysis of bone marrow-derived macrophages of mice treated with recombinant Ssa1, a protein enriched in the hypoxic secretome of Candida albicans.
Bone marrow-derived macrophages from mice were treated with recombinant Ssa1, a protein enriched in the hypoxic secretome of Candida albicans.
ORGANISM(S): Mus Musculus (mouse) 
2024-01-29 | PXD046766 | JPOST Repository
TranscriptomicsGene expression profiling in porcine chronic myocardial ischemia treated with intramyocardial injections of secretome
Closed-chest reperfused MI was induced in pigs by 90-min occlusion, followed by reperfusion of the mid LAD (day 0) and by cardiac MRI with late enhancement (LE) at day 3. At day 30 the animals received either porcine APOSEC (n=8) or placebo medium (n=8) in a randomized manner, injected into the bord...
ORGANISM(S): Sus scrofa 
2013-12-31 | E-GEOD-47397 | biostudies-arrayexpress
TranscriptomicsAnnotating the secretome of mature primary human muscle cells
The Skeletal muscle is a metabolic active tissue that secretes various proteins. These so called myokines act auto-, para- and endocrine affecting muscle physiology and exert systemic effects on other tissues and organs. Myokines are also described to play a crucial role in the pathophysiology of me...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45473 | biostudies-arrayexpress
ProteomicsProteomic analysis of renal cancer secretome
Introduction/aim: Renal cell cancer (RCC) is the most frequent kidney malignancy. Here, we aimed to analyze RCC secretome to find key molecules involved in tumor microenvironment regulation. Methods: Conditioned media from five RCC-derived cell lines (Caki-1, KIJ-265T, KIJ-308T, 786-O, and A498) and...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-02 | MSV000088490 | MassIVE
ProteomicsProteome analysis of secretory substances containing proteins, extracellular vehicles, and others secreted from Candida albicans cultured under normal and hypoxic conditions.
Candida albicans were cultured under normal and hypoxic conditions and collected secretome from the culture supernatant with centrifugation. The secretome contains secretory proteins, extracellular vehicles, and others.
ORGANISM(S): Candida Albicans 
2024-01-29 | PXD046763 | JPOST Repository
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