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ProteomicsIn-depth proteome analysis of FFPE mammary secretory carcinoma specimens
Mammary secretory carcinoma (MSC) is one of the rarest types of breast cancer accounting for less than 0.15% of all breast cancers. Traditionally, MSC is considered that it belongs to the phenotypic spectrum of basal-like triple-negative breast carcinoma (BL-TNBC). Here, we present a study of MSC fo...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD005303 | Pride
Tmt Ffpe Quantitative proteomics Secretory carcinoma 
TranscriptomicsGene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells
We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by co...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-78501 | biostudies-arrayexpress
TranscriptomicsDll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage
The introduction of GFP into the Dll1 locus has made it possible to isolate and study primary intestinal Dll1 positive cells, which constitute the secretory cell precursors of the intestine. Applying DNA array technology, we profiled the RNA changes of FACS-sorted Dll1_high/CD24_low, Dll1_high/CD24_...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-39915 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model that recapitulates the ETV6-NTRK3 fusion oncoprotein the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9354 | biostudies-arrayexpress
ProteomicsHuman oral cancer brush biopsy iTRAQ
iTRAQ-based comparison of proteins derived from oral cells collected by brush biopsy. Protein abundance levels compared between oral pre-malignant cells, oral cancer cells and healthy normal cells, all collected from human patients. Two separate iTRAQ labeled biological replicate analyses were con...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079994 | MassIVE
UnknownCharacterization of novel genetic alterations in salivary gland secretory carcinoma.
Not available
S-EPMC7113190 | biostudies-literature
TranscriptomicsHuman lung squamous cell carcinoma expression profiling
Lung squamous cell carcinoma gene expression (LSCC) is highly variable. This study discovered and validated LSCC gene expression subtypes. RNA from tumors and a common reference were hybridized to Agilent two color microarrays
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-17710 | biostudies-arrayexpress
TranscriptomicsSecretory Antibodies in Breast Milk Promote Long-Term Intestinal Homeostasis by Regulating the Gut Microbiota and Host Gene Expression.
Maintenance of intestinal homeostasis requires a healthy relationship between the commensal gut microbiota and the host immune system. Breast milk supplies the first source of antigen-specific immune protection in the gastrointestinal tract of suckling mammals, in the form of secretory immunoglobuli...
ORGANISM(S): Mus musculus 
2014-01-25 | E-GEOD-54371 | biostudies-arrayexpress
UnknownCytological and molecular characterization of secretory breast carcinoma.
Not available
S-EPMC9303577 | biostudies-literature
TranscriptomicsA lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Expression data from CD34+ hematopoietic cells transduced with control or anti-SLPI shRNA, serum starved and treated with G-CSF. CD34+ hematopoietic cells were isolated from the bone marrow of healthy individuals, transduced with lenitvirus-based RFP-expressed shRNA constructs targeting SLPI mRNA or...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-53353 | biostudies-arrayexpress
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