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ProteomicsEarly Cardiac Proteomic Profiling in a Long-Latency Doxorubicin Cardiomyopathy Model Exhibits Sexual Dimorphism for Cardioprotection
In this study, we employed large-scale data-independent acquisition (DIA) proteomics in a long-latency rat model of doxorubicin-induced cardiomyopathy to characterize early cardiac proteomic remodeling prior to overt functional decline. Male and female Sprague-Dawley rats received a cumulative low d...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD076815 | Pride
Doxorubicin Dia Proteomics Female Long latency Male Data-independent acquisition Cardiomyopathy 
ProteomicsInhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
We employed a guinea pig model of heart failure (HF) that combines ascending aortic constriction with daily administration of the β-adrenergic agonist isoproterenol (1 mg/kg/day for 1 hour) via an implanted programmable pump. The experimental groups included: 1) Sham-operated controls; 2) ACi (Aorti...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-09-08 | PXD058012 | Pride
Heart failure Guinea pig Heart P38 inhibition Tmt Lc-ms/ms 
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