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TranscriptomicsType I interferon regulates the expression of long non-coding RNAs [RNA-seq]
Interferons (IFNs) are key players in the antiviral response. IFN sensing by the cell activates transcription of IFN-stimulated genes (ISGs) able to induce an antiviral state by affecting viral replication and release. IFN also induces the expression of ISGs that function as negative regulators to l...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-64795 | biostudies-arrayexpress
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma
This SuperSeries is composed of the following subset Series: GSE25636: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset] GSE25637: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human m...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-25639 | biostudies-arrayexpress
TranscriptomicsType I interferon regulates the expression of long non-coding RNAs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-64796 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Huh7 cells treated with IFNa2, OSM or IFNa2 combined with OSM
OSM increases the antiviral effect of IFNα in Huh7 cells infected with hepatitis A virus (HAV) or HCV replicon and synergizes with IFNα in the induction of antiviral genes 16 samples. Four replicates for each experimental condition. 72 hours of treatment in DMEM supplemented with 2% FBS.
ORGANISM(S): Homo sapiens 
2009-01-20 | E-GEOD-13046 | biostudies-arrayexpress
TranscriptomicsExpression profile of MCF7, CCD18 and Ramos human cell lines
To uncover the chromosome 16 associated proteome and to take advantage of the generated knowledge to make progress in human biology in health and disease, a consortium of 15 groups was organized in four working groups: SRM and protein sequencing, antibody and peptide standard, clinical healthcare an...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-40168 | biostudies-arrayexpress
TranscriptomicsUNRAVELING A NOVEL TRANSCRIPTION FACTOR CODE INDUCTIVE FOR THE HUMAN ARTERIAL-SPECIFIC ENDOTHELIAL CELL SIGNATURE
Endothelial cells (EC) lining arteries and veins have distinct molecular and functional signatures. The (epi)genetic regulatory mechanisms underlying this heterogeneity in human EC are incompletely understood. Using genome-wide microarray screening we established a specific fingerprint of freshly is...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-43475 | biostudies-arrayexpress
TranscriptomicsSlu7 is essential for liver differentiation, metabolism and quiescence
The equilibrium between cellular differentiation and proliferation is fundamental for tissue homeostasis. This is particularly important for the liver, a highly differentiated organ with systemic metabolic functions still endowed with unparalleled regenerative potential. Hepatocellular de-differenti...
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-54090 | biostudies-arrayexpress
TranscriptomicsType I interferon regulates the expression of long non-coding RNAs [expression array]
Interferons (IFNs) are key players in the antiviral response. IFN sensing by the cell activates transcription of IFN-stimulated genes (ISGs) able to induce an antiviral state by affecting viral replication and release. IFN also induces the expression of ISGs that function as negative regulators to l...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-64794 | biostudies-arrayexpress
TranscriptomicsGenome expression profiling identifies host-directed antimicrobial drugs against respiratory infection by nontypable Haemophilus influenzae
Objectives: Therapies being safe, effective and not vulnerable to develop resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an alternative to conventional antibiotics based on perturbing host pathways subverted by pathogens during their life cycle by t...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-69134 | biostudies-arrayexpress
TranscriptomicsLineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T cell blast crisis
Deregulations in transcription factors lead to abnormal development, like in leukaemias, where chromosomal abnormalities either create chimeric TFs or alter the expression of the existing ones. The characterization of the precise functions of the TFs that regulate blood formation is essential to und...
ORGANISM(S): Mus musculus 
2016-05-30 | E-GEOD-47612 | biostudies-arrayexpress
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