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ProteomicsProfiling tissue-specific modulation of gene expression in response to insulin signalling in Drosophila
We investigated tissue-specific regulation of gene expression in a long lived Drosophila IIS mutant (dilp2-3,5) compared to its control (wDah). As in the majority of Drosophila laboratory strains, the endosymbiont Wolbachia was present; in the absence of Wolbachia, life extension through dilp2-3,5 i...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-21 | PXD011589 | Pride
Drosophila tissue-specific insulin longevity lifespan aging shotgun 
ProteomicsA proteomic atlas of insulin signaling reveals tissue-specific mechanisms of longevity-assurance
Lowered activity of the insulin/IGF signaling (IIS) network can ameliorate the effects of ageing in model organisms and, possibly, humans. Remodelling of the RNA transcriptome of long-lived IIS mutants has been extensively documented, but is only weakly predictive of consequent changes in protein ex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-09-13 | PXD006225 | Pride
Q exactive Insulin signaling Tissue specific Shotgun Drosophila melanogaster 
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