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UnknownMechanisms of peripheral sensitization in endometriosis patients with peritoneal lesions and acyclical pain.

Purpose

Endometriosis (EM) is one of the most frequent differential diagnoses concerning chronic pelvic pain. Women under hormonal therapy (HT) often benefit from it but sometimes suffer a setback and develop acyclical pelvic pain. Due to the assumption that mechanisms of neurogenic inflamma...
S-EPMC10435658 | biostudies-literature
UnknownPARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives.
More than simply a promising management option, PARP inhibitors can be regarded as a milestone in the development of personalised treatment of recurrent ovarian carcinoma. Their mechanism of action, known as "synthetic lethality", is dependent on functional differences of the DNA repair mechanisms o...
S-EPMC4771499 | biostudies-literature
UnknownManagement of Adverse Events During Rucaparib Treatment for Relapsed Ovarian Cancer: A Review of Published Studies and Practical Guidance.
The poly(ADP-ribose) polymerase inhibitor rucaparib is approved as monotherapy in the treatment and maintenance settings for women with relapsed ovarian cancer in the European Union and the United States. We review the safety profile of rucaparib in both settings and provide recommendations for the ...
S-EPMC7283207 | biostudies-literature
UnknownNeurogenic Inflammation in the Context of Endometriosis-What Do We Know?
Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic...
S-EPMC8658724 | biostudies-literature
UnknownHow to break bad news and how to learn this skill: results from an international North-Eastern German Society for Gynecological Oncology (NOGGO) survey among physicians and medical students with 1089 participants

Background

Delivering bad news to patients is one of the most challenging tasks in medical practice. Despite its great relevance to patients, relatives, and medical staff, there is a paucity of data pertaining to training, experience, expectations, and preferences of physicians and medical s...
S-EPMC10804030 | biostudies-literature
UnknownMultimodal management of ectopic hepatic pregnancy: a systematic review of the literature.

Purpose

Ectopic pregnancies with implantation in the upper abdomen are exceptionally rare. Here we provide a systematic review of hepatic ectopic pregnancies and the corresponding management strategies. Furthermore, this report details a case of ectopic hepatic pregnancy, successfully treate...
S-EPMC11485115 | biostudies-literature
Unknown"Like one part of a puzzle" - individualized aromatherapy for women with gynecological cancers in aftercare: results from a qualitative-focused mixed-methods study.

Background

Gynecological cancer(s), including breast cancer patients in aftercare and survivors, need supportive strategies to cope with symptoms that are adapted to their individual needs and circumstances. Aromatherapy has potential to be such strategy, but (qualitative) empirical research...
S-EPMC9789001 | biostudies-literature
UnknownImproving the Antigenicity of SARS-CoV-2 Vaccine Genes by Merging Mutations from Different Variants of Concern.
During the COVID-19 pandemic, the early emergence of viral variants repeatedly undermined the effects of vaccination. Our aim here is to explore strategies for improving spike vaccine gene antigenicity by merging mutations from different variants of concern (VOCs) in a single vaccine gene. To this e...
S-EPMC10975238 | biostudies-literature
UnknownPatient involvement in research within the Gynecological Cancer InterGroup: A call to action for a systematic approach: Results from a survey.

Background and aims

Involving patients in research, not only as trial subjects, is not a newly established practice. Over the last two decades, patient roles have gradually expanded to become active research contributors, creating a more patient-centered research landscape. Our survey has ex...
S-EPMC10691166 | biostudies-literature
UnknownThe serum glycome to discriminate between early-stage epithelial ovarian cancer and benign ovarian diseases.
Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers...
S-EPMC4145549 | biostudies-literature
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