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TranscriptomicsSorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
In flies, small silencing RNAs are sorted between Argonaute1 (Ago1), the central protein component of the microRNA (miRNA) pathway, and Argonaute2 (Ago2), which mediates RNA interference. Extensive double-stranded characterM-bM-^@M-^Tas is found in small interfering RNAs (siRNAs)M-bM-^@M-^Tdirects d...
ORGANISM(S): Drosophila melanogaster 
2009-10-31 | E-GEOD-18806 | biostudies-arrayexpress
TranscriptomicsEndogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA as a defense against viral infection. Here, we identify 21-nt long, endogenous siRNAs (endo-siRNAs) corresponding to transposons and heterochromatic...
ORGANISM(S): Drosophila melanogaster 
2008-04-10 | E-GEOD-11019 | biostudies-arrayexpress
TranscriptomicsmiRNA* loading on Ago2
In flies, microRNAs (miRNAs) are synthesized as a short imperfect duplex, where the miRNA is paired to another small RNA, dubbed the "miRNA*". Usually, miRNA*s are degraded in the last steps of miRNA maturation, but we found evidence that some of them can be loaded on the Ago2 protein. Sma...
ORGANISM(S): Drosophila melanogaster 
2010-08-02 | E-GEOD-12462 | biostudies-arrayexpress
UnknownProtocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency Tracheal Intubation.
Not available
S-EPMC12747562 | biostudies-literature
TranscriptomicsThe Oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs [miRNA-seq].
Using high throughput sequencing of Drosophila head RNA, a small set of miRNAs that undergo robust circadian oscillations in levels were discovered. We concentrated on a cluster of six miRNAs, mir-959-964, all of which peak at about ZT12 or lights-off. The data indicate that the cluster pri-miRNA is...
ORGANISM(S): Drosophila melanogaster 
2012-11-02 | E-GEOD-40943 | biostudies-arrayexpress
TranscriptomicsThe Smaug RNA-binding protein is essential for microRNA synthesis during the Drosophila maternal-to-zygotic transition
Background: Metazoan embryos undergo a maternal-to-zygotic transition (MZT) during which a subset of maternal gene products is eliminated and the zygotic genome becomes transcriptionally active. RNA-binding proteins (RBPs) and the microRNA-induced silencing complex (miRISC) – of which Argonaute 1 ...
ORGANISM(S): Drosophila melanogaster 
2016-09-06 | E-GEOD-82194 | biostudies-arrayexpress
GenomicsAn Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Gallus gallus 
2013-03-26 | E-GEOD-44690 | biostudies-arrayexpress
TranscriptomicsAAV vector-mediated in vivo miRNA antagonism for studying miRNA function and treating dyslipidemia
Understanding the function of individual miRNA species in mice would require the production of hundreds of loss-of-function strains. To accelerate analysis of miRNA biology in mammals, we combined recombinant adeno-associated virus (rAAV) vectors with miRNA ‘Tough Decoys’ (TuDs) to inhibit specific ...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-25971 | biostudies-arrayexpress
UnknownPreclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Not available
S-EPMC2062799 | biostudies-literature
TranscriptomicsThe Oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs.
This SuperSeries is composed of the following subset Series: GSE40894: The Oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs [expression]. GSE40943: The Oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs [miRNA-se...
ORGANISM(S): Drosophila melanogaster 
2012-11-02 | E-GEOD-40981 | biostudies-arrayexpress
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