Seizure - OmicsDI

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synthetic construct (5)
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Organisms

Mus musculus (99)
Homo sapiens (57)
Rattus norvegicus (44)
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human oral metagenome (1)
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Repository

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biostudies-arrayexpress (246)
geo (189)
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pride (27)
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Tissue

Brain (17)
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Hippocampal pyramidal layer (1)
Hippocampal pyramidal neuron (1)
Hippocampus (1)
Kidney cell (1)
Peripheral blood mononuclear cell (1)

Disease

Seizure (2)
Temporal lobe epilepsy (2)
Epilepsy (2)
Normal (1)
Early-life seizures (1)
Healthy (1)
Chronic Pain (1)
Peripheral Nervous System Diseases (1)
Not Available (1)
Brain cancer (1)
Brain glioma (1)
Complex partial epilepsy (1)
Depression (1)
Early infantile epileptic encephalopathy (1)
Epilepsy with generalized tonic-clonic seizures (1)
Generalized convulsive epilepsy (1)
Glioblastoma (1)

Technology Type

Mass Spectrometry (27)
Shotgun proteomics (14)
Mass spectrometry (6)
Bottom-up proteomics (6)
Illumina HiSeq 2000 (4)
Mass spectrometry assay (3)
Data-dependent acquisition (3)
SWATH MS (3)
ILLUMINA, Illumina HiSeq 2500 (2)
Affinity purification coupled with mass spectrometry proteomics (2)
Top-down proteomics (2)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
NMR spectroscopy assay (1)
Data-independent acquisition (1)
DiaPASEF (1)
Gel-based experiment (1)
MSE (1)

Instrument Platform

Q Exactive HF-X (7)
Illumina NovaSeq 6000 (5)
NextSeq 500 (5)
Liquid Chromatography MS - positive - reverse phase (5)
Illumina HiSeq 2500 (4)
Orbitrap Exploris 480 (4)
Orbitrap Fusion Lumos (3)
Q Exactive (3)
Scanning of was performed on an Axon 4000B scanner (2)
Illumina NovaSeq X (2)
Affymetrix (2)
Q Exactive HF (2)
G2565AA DNA microarray scanner [Agilent] (1)
Nanodrop spectrophotometer (1)
No (1)
Illumina MiSeq (1)
NextSeq 550 (1)
Illumina HiSeq 2000 (1)
Illumina HiSeq 4000 (1)
- (1)
AB 3130 Genetic Analyzer (1)
Illumina NextSeq 500 (1)
Instrument (1)
6550 iFunnel Q-TOF LC/MS (1)
Compact (1)
Exactive (1)
LTQ Orbitrap Velos (1)
Orbitrap Fusion (1)
Q Exactive Plus (1)
RP-HPLC-ESI-LTQ-Orbitrap mass analyser (1)

Publication Date

2026 (46)
2023 (46)
2008 (37)
2013 (35)
2014 (32)
2011 (32)
2015 (31)
2024 (28)
2016 (28)
2025 (25)
2022 (25)
2010 (23)
2021 (20)
2012 (17)
2007 (17)
2020 (16)
2019 (13)
2009 (13)
2017 (9)
2005 (5)
2018 (5)
2004 (4)
2006 (2)
2003 (1)

UNIPROT ID/AC

C9JM50 (6)
O95678 (6)
P02533 (6)
P02538 (6)
P04259 (6)
P04264 (6)
P05787 (6)
P07477 (6)
P08727 (6)
P08729 (6)
P08779 (6)
P12035 (6)
P13645 (6)
P13646 (6)
P13647 (6)
P19012 (6)
P19013 (6)
P35527 (6)
P35908 (6)
P48668 (6)
Q01546 (6)
Q04695 (6)
Q14CN4 (6)
Q3SY84 (6)
Q5XKE5 (6)
Q7RTS7 (6)
Q7Z3Y7 (6)
Q7Z3Y8 (6)
Q7Z3Z0 (6)
Q7Z794 (6)

ENSEMBL ID

ENSG00000170477 (6)

CHEBI ID

CHEBI:10275 (1)
CHEBI:1148 (1)
CHEBI:132926 (1)
CHEBI:133089 (1)
CHEBI:133096 (1)
CHEBI:133672 (1)
CHEBI:133734 (1)
CHEBI:134218 (1)
CHEBI:134270 (1)
CHEBI:134435 (1)
CHEBI:134648 (1)
CHEBI:135593 (1)
CHEBI:135918 (1)
CHEBI:136196 (1)
CHEBI:136276 (1)
CHEBI:136982 (1)
CHEBI:137214 (1)
CHEBI:138017 (1)
CHEBI:138460 (1)
CHEBI:141348 (1)
CHEBI:144643 (1)
CHEBI:145254 (1)
CHEBI:145263 (1)
CHEBI:145292 (1)
CHEBI:156044 (1)
CHEBI:156118 (1)
CHEBI:156198 (1)
CHEBI:16196 (1)
CHEBI:16283 (1)
CHEBI:16414 (1)

Metabolite Name

(+)-(1R,2R)-1,2-Diphenylethane-1,2-diol; (E)-2-(2,4-Hexadiynylidene)-1,6-dioxaspiro[4.5]dec-3-ene; Ethyl 1-naphthylacetic acid; 1,2-diphenylethane-1,2-diol; (1)
(2,6-dihydroxy-4-{7-methyl-11-oxo-4-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-2,8-dioxatricyclo[7.3.1.0â?Â¹Â³]trideca-1(12),3,5(13),6,9-pentaen-3-yl}phenoxy)dihydroxyoxo-Î»â?sulfanylium; (1)
(2S,3R)-3-Hydroxy-2-methylbutanoic acid; 2-Methyl-3-hydroxybutyric acid; 2-Ethylhydracrylic acid; 2-Hydroxy-3-methylbutyric acid; 3-Hydroxy-2-methyl-[S-(R,R)]-butanoic acid; (1)
(2S,4R,6S)-2-[2-(4-hydroxy-3-methoxyphenyl)ethyl]tetrahydro-6-(4-hydroxy-3,5-dimethoxyphenyl)-2H-pyran-4-ol; Mammeigin; Dihydroclusin; Furomammea D; Fragransin B2; (1)
(E)-2-octenal; 2-Octenal; (3xi,5Z)-1,5-Octadien-3-ol; 2,4,4-Trimethylcyclopentanone; 2-Octen-4-one; (1)
(R)-3-Hydroxy-5-phenylpentanoic acid; 2,5-Dimethoxy-4-(2-propenyl)phenol; Butylparaben; Zingerone; Ethyl 4-methylphenoxyacetate; (1)
(Â±)-Ribaline; 5-Amino-6-(4-hydroxy-2-butenoyl)-2,2-dimethyl-4-chromanone; (1)
1-(5-Fluoropentyl)-3-(2-Iodobenzoyl)Indole (1)
1-Isothiocyanato-8-(methylthio)octane; (1)
1-O-(2r-Hydroxy-4z-Pentadecenyl)-Sn-Glycerol (1)
17-Hydroxy Stearic Acid (1)
2,3-Dihydro-5-(5-methyl-2-furanyl)-1H-pyrrolizine; (1)
2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) (1)
2,5-Dihydro-2,4,5-trimethyloxazole; 1-Piperidinecarboxaldehyde; 2-Acetylpyrrolidine; Epsilon-caprolactam; (1)
2-(2,5-dihydroxy-4-methoxyphenyl)-3,5,6,7-tetrahydroxy-3,4-dihydro-2H-1-benzopyran-4-one; 3-(2,5-dihydroxy-4-methoxyphenyl)-1-(2,3,4,6-tetrahydroxyphenyl)propane-1,2-dione; 3,5,7-trihydroxy-6-methoxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; 3,5,7-trihydroxy-6-methoxy-2-(2,3,4-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; 3,5,7-trihydroxy-6-methoxy-2-(2,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (1)
2-(5,8-Tetradecadienyl)Cyclobutanone (1)
2-(acetylamino)-1,5-anhydro-2-deoxy-3-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol; 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol; (1)
2-Aminoethyl Oleate (1)
2-Benzoxazolol; (1)
2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one; Vanilloylglycine; 2-{[hydroxy(3-hydroxy-5-methoxyphenyl)methylidene]amino}acetic acid; 2-{[hydroxy(2-hydroxy-4-methoxyphenyl)methylidene]amino}acetic acid; 2-{[hydroxy(3-hydroxy-4-methoxyphenyl)methylidene]amino}acetic acid; (1)
2-Hydroxycinnamic Acid (1)
2-Tetradecylcyclobutanone (1)
2-amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-{[2-hydroxy-2-methoxy-1-(7-methyl-2-oxo-2H-chromen-6-yl)ethyl]sulfanyl}ethyl}-C-hydroxycarbonimidoyl)butanoic acid; (1)
2-b-D-glucopyranosyloxy-4,7-dimethoxy-1,4-benzoxazin-3-one (HDMBOA glucoside) (1)
2-b-D-glucopyranosyloxy-4-hydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA glucoside) (1)
2e,13z-Octadecadienal (1)
3',5'-Diiodo-L-thyronine 4'-O-sulfate; (1)
3-(3,5-Diiodo-4-hydroxyphenyl)lactate; (1)
3-Hydroxyisoheptanoic acid; (+/-)-Ethyl 2-hydroxy-2-methylbutyrate; Methyl DL-Leucate; Methyl (Â±)-3-hydroxyhexanoate; Butyl lactate; (1)
3-Hydroxyoctadecanoylcarnitine (1)

First Public Date

2026 (53)
2014 (49)
2023 (41)
2024 (28)
2025 (26)
2020 (15)
2021 (12)
2019 (12)
2022 (9)
2017 (8)
2018 (7)
2015 (6)
2016 (5)
2013 (2)

Study status

Not yet recruiting (1)
Recruiting (1)

Study type

Transcription profiling by array (168)
RNA-seq of coding RNA (24)
Unknown experiment type (10)
Methylation profiling by array (8)
Comparative genomic hybridization by array (7)
Methylation profiling by high throughput sequencing (6)
ChIP-chip by tiling array (3)
DNA-seq (3)
Transcription profiling by SAGE (2)
Animal - High-throughput sequencing (2)
Transcription profiling by RT-PCR (2)
Other (2)
ChIP-seq (2)
RNA-seq of non coding RNA (2)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
MicroRNA profiling by array (1)
RNA-seq of total RNA (1)
Interventional (1)
Observational (1)

Release Date

2022 (886)
2025 (835)
2023 (817)
2021 (737)
2024 (705)
2020 (587)
2019 (442)
2018 (358)
2017 (317)
2016 (273)
2015 (244)
2014 (200)
2026 (141)
2013 (136)
2012 (96)
2011 (86)
2010 (76)
2008 (59)
2009 (42)
2007 (29)
2006 (13)
2005 (9)
2004 (7)
2003 (6)
2001 (5)
2000 (3)
2002 (1)
1997 (1)

Lab affiliation

Biomedical Sciences , Iowa State University (1)
Biosciences Institute, Newcastle University, Newcastle, UK (1)
Bourne Laboratory, Department of Biological Science, Royal Holloway University of London, Egham, Surrey, TW20 OEX, UK (1)
Department of Biological Sciences The University of Texas at El Paso US (1)
Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Korea (1)
Department of Biomedical Sciences, University of Sassari, Sassari, Italy (1)
Department of Cellular Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Laboratory Nº12 (1)
Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, 3000, Victoria, Australia. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, 3004, Victoria, Australia. (1)
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (1)
Department of Neurology School of Medicine Oregon Health & Science University Portland, OR, USA (1)
Department of Neurosurgery, Neurosurgical Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China (1)
Department of Pharmacology & Chemical Biology W1351 Thomas Starzl Biomedical Science Tower, 200 Lothrop St,Pittsburgh, PA 15261 (1)
Department of Radiation Oncology. Weill Cornell Medicine, New York (1)
Div. Cell Biology, Biocenter, Medical University Innsbruck, Austria (1)
Epilepsy Research Laboratory Department of Biomedical Sciences College of Veterinary Medicine Iowa State University Ames Iowa 50011-1250 USA (1)
Goethe University Frankfurt, Institute of molecular systems medicine (1)
Inserm, CESP, Equipe « Moods » Université Paris Saclay - Batiment Henri Moissan 19 avenue des Sciences 91400 Orsay France (1)
Institute of Physiology II, University of Freiburg, Germany (1)
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium (1)
Nanyang Technological University (1)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (1)
School of Life Sciences and Technology, Tongji University, Shanghai, China (1)
University of Nebraska, Lincoln (1)
University of Southern Denmark, Department og Biochemistry and Molecular Biology (1)
Wallenberg Center of Molecular and Translational Medicine,Sahlgrenska Academy, University of Gothenburg, Sweden (1)
Zhejiang Pharmaceutical University (1)
[1] QC-MS / Fa. Dr. Loroch, BioMedizinZentrum, Otto-Hahn-Straße 15, 44149 Dortmund [2] Medizinisches Proteom-Center, Center for Protein Diagnostics (PRODI), Medical Faculty, Ruhr-University Bochum, Bochum, Germany (1)

Location

Australia (1)
Bangladesh (1)

Keyword

Lidocaine (1)

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Total and synaptosomal proteomic analysis

Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-03-19 | MSV000091510 | MassIVE

microRNAs profiling in hippocampal cells of mouse with Sound-induced Seizure

After an electrically induced seizure, mice (NMRI) received electrical stimulation (current intensity 44 mA, 0.2 ms monopolar pulses at 6 Hz frequency for 3 s). RNA was extracted from the hippocampi at 0, 3, 6, 24 and 72 h after the seizure. microRNA expressions were measured via microarray technolo...

ORGANISM(S): Mus musculus

2014-01-01 | E-GEOD-51840 | biostudies-arrayexpress

Transcription profiling of mouse brains following nicotine-induced seizures

Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to...

ORGANISM(S): Mus musculus

2008-04-09 | E-GEOD-6614 | biostudies-arrayexpress

Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy

The molecular basis of epileptogenesis is poorly characterized. Studies in humans and animal models have identified an electrophysiological signature that precedes the onset of epilepsy, which has been termed fast ripples (FRs) based on its frequency. Multiple lines of evidence implicate regions gen...

ORGANISM(S): Rattus norvegicus

2015-05-01 | E-GEOD-68430 | biostudies-arrayexpress

Transcription profiling of hippocampi of rats that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30

Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effe...

ORGANISM(S): Rattus norvegicus

2007-09-14 | E-GEOD-1833 | biostudies-arrayexpress

LFQ proteomics of isolated GABAergic interneurons from mouse models of traumatic brain injury

Posttraumatic epilepsy (PTE) is a major public health concern and strongly contributes to human epilepsy cases worldwide. However, their effective treatment and prevention remains a matter of intense research. The present study provides new insights into the GABAA-receptor-stabilizing protein ubiqui...

ORGANISM(S): Mus Musculus (mouse)

2022-07-14 | PXD031368 | JPOST Repository

Rnf41 is associated with anxiety like behavior, major depression and beta carboline induced seizure

The molecular etiology of invididual differences in complex behavior traits and susceptibility to psychiatric illness remains incomplete. Using an unbiased genetic approach in a mouse model, Quantitative Trait Loci (QTL) influencing anxiety-like behaviors and beta-carboline-induced seizure vulnerabi...

ORGANISM(S): Mus musculus

2010-05-25 | E-GEOD-8641 | biostudies-arrayexpress

Transcriptome Profiling of Hippocampal CA1 After Early Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies for Epilepsy

Injury of the CA1 subregion induced by a single injection of kainic acid (1M-CM-^WKA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning...

ORGANISM(S): Rattus norvegicus

2013-02-14 | E-GEOD-44031 | biostudies-arrayexpress

Does Missing Medication Acutely Change Seizure Risk? A Prospective Study.

Not available

S-EPMC12782288 | biostudies-literature

Changes in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights

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INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

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