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ProteomicsSelective Inhibition of MTHFD1/2 in T Cells from Patients with Rheumatoid Arthritis
Ex vivo T cell treatment Immunomagnetic negative isolation was used to obtain untouched human T cells from previously frozen PBMC samples of treatment-naïve (n=6) and MTX-IR (n=3) RA patients (Table S1). The isolated T cells were then cultured and stimulated in a 96-well round-bottom plates for susp...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD061849 | Pride
Proteomics Methotrexate Selective mthfd1/2 inhibitor T cells Rheumatoid arthritis 
UnknownStructure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Not available
S-EPMC6580548 | biostudies-literature
TranscriptomicsTranscription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine dendritic cells in the presence and absence of interferon (IFN)-gamma to identify a tolerogenic signature in IDO-competent dendritic cells.
Although much is known on the transcriptional profiles of dendritic cells (DCs) during maturation, the molecular switches critical for the acquisition of a tolerogenic program by DCs are still obscure. In the present study, we explored the gene expression pattern of CD8+ DCs purified from the mouse ...
ORGANISM(S): Mus musculus 
2007-09-11 | E-GEOD-3337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dendritic monocytes treated with LPS (lipopolysaccharide) or CyP (Cyanobacterial Product) reveals cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. We report the identification and biologic characterization of an LPS-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (CyP).
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4748 | biostudies-arrayexpress
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