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ProteomicsCopper impairs hepatic selenoprotein P release
Selenoprotein P is a hepatokine which is essential for maintaining systemic selenium homeostasis and is used as serum biomarker for the selenium status in humans. In addition to selenium, also copper homeostasis is mainly regulated by the liver coordinating systemic distribution of copper bound to c...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036300 | Pride
Selenoprotein p Wilson’s disease Selenium Copper Secretome 
TranscriptomicsDeficiency in the 15 kDa Selenoprotein Inhibits Tumorigenicity and Metastasis of Colon Cancer Cells
Selenium has cancer preventive activity that is mediated, in part, through selenoproteins. The role of the 15 kDa selenoprotein (Sep15) in colon cancer was assessed by preparing and using mouse colon CT26 cells stably transfected with shRNA constructs targeting Sep15. Metabolic 75Se-labeling and Nor...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-20390 | biostudies-arrayexpress
TranscriptomicsKnockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage
Comparative analysis of gene expression in bone marrow-derived macrophages (BMDM) from trsp knockout mice (Trspfl/fl-LysM-Cre+/-) and Control (Trspfl/fl-LysM-Cre-/-) mice. Selenium, a micronutrient whose deficiency in the diet causes immune dysfunction and inflammatory disorders, exerts its physio...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress
TranscriptomicsWild type mice (Trsp) vs Trsp-knockout mice (DTrsp) or A34 or G37L or G37H transgenic mice
Comparative analysis of gene expression in the liver of the Trsp-knockout mice (Trspfl/fl-AlbCre+/+) and A34 (Trspfl/fl-AlbCre+/+-A34t/t), G37L (Trspfl/fl-AlbCre+/+-G37t/t; 2 copies), G37H (Trspfl/fl-AlbCre+/+-G37t/t; 16 copies) transgenic mice with gene expression of wild type mice (Trsp+/+-AlbCre...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12495 | biostudies-arrayexpress
UnknownThe selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.
Not available
S-EPMC1919489 | biostudies-literature
UnknownAlcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Not available
S-EPMC7937717 | biostudies-literature
UnknownSelenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.
Not available
S-EPMC10232449 | biostudies-literature
UnknownSelenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.
Not available
S-EPMC10954901 | biostudies-literature
UnknownImmune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P.
Not available
S-EPMC12373998 | biostudies-literature
UnknownGenetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes.
Not available
S-EPMC6045871 | biostudies-literature
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