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TranscriptomicsTranscription profiling by array of human HT29 colon cancer cells to investigate the role of Caveolin 1, E-Cadherin, Enolase 2 and PKCa on resistance to methotrexate
A summary of the work associated to these microarrays is the following:; Methotrexate (MTX) is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for different types of...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HT29 cells sensitive and resistant to 10e-5M methotrexate
The abstract of the associated publication (Selga E, Noé V, Ciudad CJ. Biochemical Pharmacology 2007 Sep 8; Article in press) is the following:; While studying differentially expressed genes between sensitive and 10-5 M Methotrexate (MTX) resistant HT29 human colon cancer cells, we identified some ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9412 | biostudies-arrayexpress
TranscriptomicsUnderexpression of miR-224 in methotrexate resistant human colon cancer cells
A summary of the work associated to these microarrays is the following: MicroRNAs (miRNAs) are small non-coding RNAs involved in RNA silencing that play a role in many biological processes. They are involved in the development of many diseases, including cancer. Extensive experimental data show tha...
ORGANISM(S): Homo sapiens 
2013-05-29 | E-GEOD-28547 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat mesenteric lymph nodes upon supplementation with conjugated linoleic acid during gestation and suckling
A summary of the work associated to these microarrays is the following: Diet plays a role in the development of the immune system, and polyunsaturated fatty acids can modulate the expression of a variety of genes. Human milk contains conjugated linoleic acid (CLA), a fatty acid that seems to contri...
ORGANISM(S): Rattus norvegicus 
2011-07-21 | E-GEOD-23004 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in human K562 erythtoblastic leukemia cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16085 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in human Saos-2 osteosarcoma cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through ...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16089 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in CaCo2 human colon cancer cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16066 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in human MDA-MB-468 breast cancer cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16080 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in human MIA PaCa2 pancreatic cancer cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through ...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16082 | biostudies-arrayexpress
TranscriptomicsNetworking of differentially expressed genes in human MCF7 breast cancer cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16070 | biostudies-arrayexpress
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