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TranscriptomicsReduction of DNA methylation suppresses colon carcinogenesis through induction of tumor cell differentiation
In this study, we analyzed global gene expressions of colon tumors from DNA hypomethylated and the control mice. We found that DNA hypomethylated tumors express significantly higher levels of intestinal differentiation-related genes when compared with the control tumors. These results suggest that D...
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-60620 | biostudies-arrayexpress
GenomicsPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [RRBS]
We report a reprogrammable mouse system in which reprogramming factor expression in vivo can be controlled temporally by treatment with doxycycline (Dox). Transient expression of reprogramming factors in vivo results in tumor development in various tissues, consisting of undifferentiated dysplastic...
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-52303 | biostudies-arrayexpress
TranscriptomicsPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
We report a reprogrammable mouse system in which reprogramming factor expression in vivo can be controlled temporally by treatment with doxycycline (Dox). Transient expression of reprogramming factors in vivo results in tumor development in various tissues, consisting of undifferentiated dysplastic...
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-51786 | biostudies-arrayexpress
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