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ProteomicsQuantitative proteomic characterization of senile plaques from Alzheimer's disease and non-demented brain
The deposition of amyloid senile plaques (SPs) play a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasising SPs have had limited success in reproducing the neuropathology of AD, and have also fai...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD005824 | Pride
Human Brain Alzheimer's disease Amyloid plaque Senile plaque 
ProteomicsQuantitative proteomic characterization of senile plaques from APP/PS1 mice brain
The deposition of amyloid senile plaques (SPs) plays a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasizing SPs have had limited success in reproducing the neuropathology of AD, and have also fa...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-20 | PXD005876 | Pride
Brain Mouse Alzheimer's disease Amyloid plaque Senile plaque 
TranscriptomicsExpression profiling of laser-microdissected tissue from APPPS1 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15058 | biostudies-arrayexpress
TranscriptomicsmicroRNA-132/212 deficiency enhances Ab production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
The abnormal regulation of amyloid-b (Ab) metabolism (e.g., production, cleavage, clearance) plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to participate in AD progression are the small regulatory non-coding microRNAs (miRs). In particular, the miR-132/212 clu...
ORGANISM(S): Mus musculus 
2016-07-17 | E-GEOD-84481 | biostudies-arrayexpress
TranscriptomicsmicroRNA-132/212 deficiency enhances Ab production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
The abnormal regulation of amyloid-b (Ab) metabolism (e.g., production, cleavage, clearance) plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to participate in AD progression are the small regulatory non-coding microRNAs (miRs). In particular, the miR-132/212 clust...
ORGANISM(S): Mus musculus 
2016-07-17 | GSE84481 | GEO
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress
TranscriptomicsExpression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15056 | biostudies-arrayexpress
UnknownmicroRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice.
Not available
S-EPMC4971468 | biostudies-literature
UnknownThe senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Not available
S-EPMC10097081 | biostudies-literature
TranscriptomicsLaser-microdissected tissue from Tg2576 and APPPS1 plaque-depositing mouse model of Alzheimer's disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15128 | biostudies-arrayexpress
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