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ProteomicsIdentification of SENP6 target proteins by endogenous SUMO2/3 IP-MS
Cellular signaling by the ubiquitin-related SUMO pathway relies on coordinated conjugation and deconjugation events. SUMO-specific deconjugating enzymes counterbalance SUMOylation, but comprehensive insight into their substrate specificity and regulation is missing. By characterizing SENP6 we define...
ORGANISM(S): Homo sapiens (Human) 
2019-11-20 | PXD015134 | Pride
Sumo Human Senp Lc-ms/ms 
GenomicsSENP6 loss in BCL
Loss of SENP6 drives genetic instability in B-cell lymphoma
PRJEB44263 | ENA
ProteomicsThe SUMO protease SENP6 regulates the constitutive centromere-associated network by group
Project 1: Identification of SUMOylated proteins which are regulated by the SUMO protease SENP6. SENP6 knockdown was performed by two independent shRNAs and SUMOylated proteins were purified from U2OS expressing His10-tagged SUMO2 by means of Ni-NTA pulldown. Purified SUMOylated proteins were identi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD011963 | Pride
Human osteosacrcoma cell line u2os Chromatin Senp6 
ProteomicsIdentification of SENP6 targets in HeLa cells by SENP6 SiRNA and MW shift analysis
The SUMO protease SENP6 disassembles SUMO chains and thus SENP6 depletion should lead to the extension of SUMO polymers on substrates. We have used a proteomic method to identify putative SENP6 substrates based on increased apparent molecular weight after SENP6 depletion. This method uses SDS-PAGE f...
ORGANISM(S): Homo sapiens (Human) 
2024-03-01 | PXD036743 | Pride
Sumo senp6 molecular weight 
TranscriptomicsGenetic alterations of SENP6 disrupt DNA repair and proteostasis conferring sensitivity to proteasome inhibition in multiple myeloma
Targeting of the ubiquitin-proteasome system (UPS) remains a mainstay in the treatment of multiple myeloma (MM). Hyperactivation of the closely related SUMO pathway is implicated in disease progression and associated with poor prognosis. Here we investigated the functional imbalance of aberrant SUMO...
ORGANISM(S): Homo sapiens 
2025-12-08 | GSE303255 | GEO
TranscriptomicsH3K9me3 CUT&RUN of mouse bone-marrow–derived macrophages and osteoclast precursors (RANKL-16h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed H3K9me3 CUT&RUN on WT and Senp6^LysM BMMs stimulated with RANKL for 16 h (R16) corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-17175 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse bone-marrow–derived macrophages and osteoclast precursors (BMM, RANKL-16h, RANKL-36h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed RNA-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-16140 | biostudies-arrayexpress
TranscriptomicsATAC-seq of mouse bone-marrow–derived macrophages and osteoclast precursors (BMM, RANKL-16h, RANKL-36h) from wild-type and Senp6 conditional knockout mice
To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed ATAC-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-16167 | biostudies-arrayexpress
TranscriptomicsActionable genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma
SUMOylation is a post-translational modification of proteins that regulates these proteins’ localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide transposon mutagenesis screen in a MYC-driven B-cell lymphoma model,...
ORGANISM(S): Homo sapiens 
2021-07-16 | GSE180052 | GEO
ProteomicsProteomes of chromatin fractions derived from SU-DHL-5 cells
SU-DHL-5 cells display limited expression of the SUMO isopeptidase SENP6. In this experiment, the chromatin associated fraction of SU-DHL-5 cells was analysed by mass spectrometry. SU-DHL-5 cells were either stably transfected with an empty vector or with a SENP6 expression construct. Changes in pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027355 | Pride
Su-dhl-5 cells (b-cell lymphoma) 
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