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TranscriptomicsWhole transcriptome analysis of FACS purified somatosensory neuron subtypes and whole dorsal root ganglia tissue
The goal of this study was to analyze global gene expression in specific populations of somatosensory neurons in the periphery, including major, non-overlapping populations that include nociceptors, pruriceptors, and prorioceptors. The mammalian somatosensory nervous system encodes the perception of...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-55114 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine neurons in the nodose and dorsal root ganglia to elucidate molecular characteristics of different sensory neorons.
Vagal afferent neurons are thought to convey primarily physiological information, whereas spinal afferents transmit noxious signals from the viscera to the central nervous system. In order to elucidate molecular identities for these different properties, we compared gene expression profiles of neu...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2917 | biostudies-arrayexpress
ProteomicsIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-09 | MSV000091027 | MassIVE
TranscriptomicsTranscription profiling of mouse spinal and trigeminal sensory ganglia of Brn3a knockout and wild type mice reveals conserved and distinct regulatory targets of Brn3a at different levels of the sensory axis
General somatic sensation is conveyed to the central nervous system at cranial levels by the trigeminal ganglion (TG), and at spinal levels by the dorsal root ganglia (DRG). Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons origina...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5658 | biostudies-arrayexpress
TranscriptomicsThe star-nosed mole reveals clues to the molecular basis of mammalian touch.
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demo...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47480 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of single cells from the mouse lumbar dorsal root ganglion
In order to establish a consensus catalog of dorsal rott ganglion cell types, we used comprehensive transcriptome analysis of single cells for unsupervised identification and molecular classification of sensory neurons independent of any a priori knowledge of sensory subtypes. RNA-Seq was performed ...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-59739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of nodose or dorsal root ganglion visceral sensory neurons from mice infected with N. brasiliensis and/or subjected to environmental stress to determine molecular signatures for post-infective visceral chemosensitivity associated with irritable bowel syndrome
Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via spinal afferents. Both stress and inflammation are implicated in visceral hypersensitivity, but the underlying molecular mechanisms of visce...
ORGANISM(S): Mus musculus 
2008-01-31 | E-JJRD-1 | biostudies-arrayexpress
TranscriptomicsExpression data from FACS purified nociceptor neurons from peripheral sensory ganglia
The goal of this study was to analyze global gene expression in specific populations of nociceptor sensory neurons, the neurons that detect damaging/noxious stimuli. The dorsal root ganglia (DRG), trigeminal ganglia, and nodose ganglia are anatomically distinct peripheral sensory ganglia that contai...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46546 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis reveals differences between embryonic and adult dorsal root ganglion axonal mRNAs that are implicated in axonal growth and pain
Local protein synthesis in sensory neuron axons is necessary for axonal regeneration with the efficiency of regeneration decreasing with age. Because the full repertoire of transcripts in embryonic and adult rat sensory axons is unknown we asked how the pool of mRNAs dynamically changes during age...
ORGANISM(S): Rattus norvegicus 
2010-11-23 | E-GEOD-22638 | biostudies-arrayexpress
TranscriptomicsSignaling to Transcription Networks in the Neuronal Retrograde Injury Response
Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate ~900 phosphop...
ORGANISM(S): Rattus norvegicus 
2010-12-29 | E-GEOD-26350 | biostudies-arrayexpress
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