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GenomicsWhole-genome landscape of histone H2AX and M-NM-3-H2AX
Phosphorylation of the histone variant H2AX forms M-NM-3-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and M-NM-3-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endoge...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
TranscriptomicsIdentification of transcripts predominantly expressed in cultured chicken primordial germ cells and embryonic fibroblasts.
The present investigation was to identify the signaling and metabolic pathways of expressed genes by microarray comparison between Primordial Germ Cells (PGCs) and their somatic counterpart, chicken embryonic fibroblasts (CEFs). We identified a total of 2,605 expressed transcripts. Among these, 1,19...
ORGANISM(S): Gallus gallus 
2013-01-10 | E-GEOD-38168 | biostudies-arrayexpress
TranscriptomicsDifferential blood biomarkers and PBMC transcriptome profiles in normal-weight and obese individuals
The aim of study was to investigate correlation bewteen peripheral blood mononuclear cell (PBMC) transcriptome profiles and plasma lipid profiles of Korean adult with varying BMI. In Korean, BMI cut-off points are 18.5~22.9 kg/m2 (normal range), M-bM-^IM-% 23 kg/m2 (overweight), M-bM-^IM-% 25 kg/m2 ...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-55205 | biostudies-arrayexpress
TranscriptomicsHuman bone and marrow niche formation by mesenchymal progenitors in vivo is predefined by an organotypic epigenetic signature
In this study, we have analyzed DNA methylation characteristics of human mesenchymal stem and progenitor cells (MSPCs) form different tissue sources including bone marrow (BM), white adipose tissue (WAT ), umbilical cord (UC) as well as dermal fibroblasts by using the HumanMethylation450K array. Cel...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-41933 | biostudies-arrayexpress
TranscriptomicsAntidiabetic Rosiglitazone Remodels the Adipocyte Transcriptome by Redistributing Transcription to PPARg-Driven Enhancers [HTS]
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for PPARg, the adipocyte-predominant nuclear receptor (NR). The classic model, involving binding of ligand to the NR on DNA, explains p...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-56745 | biostudies-arrayexpress
TranscriptomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females [aCGH]
One of the most fertile applications of next generation sequencing will be in the field of cancer genomics. Here, we report a high-throughput multi-dimensional sequencing study of primary non-small cell lung adenocarcinoma tumors and adjacent normal tissues of 6 never-smoker Korean female patients. ...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37759 | biostudies-arrayexpress
TranscriptomicsImplications of time-series gene expression profiles of replicative senescence
Although senescence has long been implicated in aging-associated pathologies, it is not clearly understood how senescent cells are linked to these diseases. To address this knowledge gap, we profiled cellular senescence phenotypes and mRNA expression patterns during replicative senescence in human d...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-41714 | biostudies-arrayexpress
ProteomicsA proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and its overall incidence has been increasing gradually over the years. Extracellular vesicles (EVs) are known to express the properties of their parental cells, including proteins, RNAs, and DNAs. As EVs are representa...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD022758 | Pride
Proteomics Q-exactive Cell Evs Aml 
UnknownSide-Chain Control of Topochemical Polymer Single Crystals with Tunable Elastic Modulus.
Not available
S-EPMC10092176 | biostudies-literature
UnknownGRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia.
Not available
S-EPMC6517657 | biostudies-literature
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