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TranscriptomicsGene expression analysis in cortex of CRTC1 deficient mice and WT littermates
To identify gene expression changes associated with Crtc1 deficiency, we performed genome-wide transcriptome profile analyses by using mouse cDNA microarrays in the cortex of Crtc1‒/‒ and WT female mice BACKGROUND: Recent studies involve the arginine-decarboxylation product agmatine in mood regu...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-80633 | biostudies-arrayexpress
TranscriptomicsGene expression data from mouse HDAC4 KO pups, postnatal day 3
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa coun...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-49383 | biostudies-arrayexpress
UnknownDecreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.
Not available
S-EPMC3136499 | biostudies-literature
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38219 | biostudies-arrayexpress
UnknownGenetic knockout of NTRK2 by CRISPR/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells.
Not available
S-EPMC10757602 | biostudies-literature
UnknownInvolvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.
Not available
S-EPMC5545706 | biostudies-literature
TranscriptomicsHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38237 | biostudies-arrayexpress
UnknownDecreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse.
Not available
S-EPMC5611741 | biostudies-literature
UnknownTargeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD.
Not available
S-EPMC11448013 | biostudies-literature
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