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ProteomicsHuman recombinant relaxin-2 (serelaxin) regulates the proteome, lipidome, lipid metabolism and inflammatory profile of rat visceral adipose tissue.
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several cardiovascular diseases (CVD). Considering these effects, together with the influence of relaxin-2 on adi...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-23 | PXD048506 | Pride
Lipolysis metabolism Inflammation Serelaxin Lipidome Visceral adipose tissue Proteome 
UnknownSerelaxin improves cardiac and renal function in DOCA-salt hypertensive rats.
Not available
S-EPMC5574886 | biostudies-literature
UnknownSerelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance.
Not available
S-EPMC5359255 | biostudies-literature
UnknownSerelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway.
Not available
S-EPMC10179109 | biostudies-literature
UnknownA phase 2 randomised controlled trial of serelaxin to lower portal pressure in cirrhosis (STOPP).
Not available
S-EPMC7066808 | biostudies-literature
UnknownVascular effects of serelaxin in patients with stable coronary artery disease: a randomized placebo-controlled trial.
Not available
S-EPMC7797213 | biostudies-literature
UnknownSerelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes.
Not available
S-EPMC5220363 | biostudies-literature
UnknownPharmacokinetics of serelaxin in patients with hepatic impairment: a single-dose, open-label, parallel group study.
Not available
S-EPMC4456126 | biostudies-literature
UnknownA randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure.
Not available
S-EPMC3924183 | biostudies-literature
UnknownDisconnect between the effects of serelaxin on renal function and outcome in acute heart failure.
Not available
S-EPMC10293419 | biostudies-literature
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