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ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
ProteomicsCharacterization of serine proteases from Canavalia ensiformis leaf
Serine proteases has been vastly reported to be found (and identified) only in seed extracts of Canavalia ensiformis (C. ensiformis), however, our group observed expressive serine protease activities in aqueous extracts from leaves, seeds, roots, and stem, especially in a leaf extract obtained with ...
ORGANISM(S): Canavalia ensiformis 
2020-08-28 | PXD010569 | Pride
Serine proteases Canavalia ensiformis Purification 
ProteomicsFunctional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Dysregulated proteolysis plays a pivotal role in the pathophysiology of inflammatory bowel disease. Nonetheless, the identity of overactive proteases released by human colonic mucosa remains unknown. Herein, we employed a serine protease-targeted activity-based probe (ABP) coupled with mass spectral...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD009450 | Pride
Inflammation Functional proteomics Activity-based probe Serine protease Inflammatory bowel disease 
ProteomicsDruggable Serine Proteases of Leishmania by Activity‐Based Protein Profiling
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of action, are urgently needed to treat the disease. Alt...
ORGANISM(S): Leishmania mexicana 
2022-07-04 | PXD033616 | Pride
Activity-based protein profiling Leishmania Serine protease 
GenomicsSingle cell sequencing identifies serine proteases as regulators of myofibroblast differentiation
Single cell sequencing identifies serine proteases as regulators of myofibroblast differentiation
PRJNA657534 | ENA
UnknownMembrane-anchored serine proteases as regulators of epithelial function.
Not available
S-EPMC9869603 | biostudies-literature
UnknownMembrane-Anchored Serine Proteases: Host Cell Factors in Proteolytic Activation of Viral Glycoproteins
Not available
S-EPMC7122464 | biostudies-literature
ProteomicsStaphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases
Staphylococcus aureus is a gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. The antibiotic treatment of S. aureus infection is often hindered by several resistances expressed by the pathogen, and therefore alternati...
ORGANISM(S): Staphylococcus Arlettae (ncbitaxon:29378) 
2024-10-14 | MSV000096077 | MassIVE
UnknownSerine proteases.
Not available
S-EPMC2675663 | biostudies-literature
UnknownExtracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization.
Not available
S-EPMC7917122 | biostudies-literature
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