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ProteomicsAttenuated palmitoylation of serotonin receptor 5-HT1A in brain affects receptor functions and triggers depressive symptoms
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are critically implicated in major depressive disorder (MDD), although underlying mechanisms remain enigmatic. Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains and identified ZDHHC21 as a major pa...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD012736 | Pride
Suicide Depression Mirna Zdhhc Palmitoylation Serotonin 5-ht1a receptor 
ModelsChang2008 - ERK activation, hallucinogenic drugs mediated signalling through serotonin receptors
Chang2008 - ERK activation, hallucinogenic drugs mediated signalling through serotonin receptors This model is described in the article: Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathemat...
2005-01-01 | MODEL0975191032 | BioModels
UnknownOncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Not available
S-EPMC6214143 | biostudies-literature
GenomicsDopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons
Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons
PRJNA513844 | ENA
UnknownSerotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression.
Not available
S-EPMC7795278 | biostudies-literature
Unknown5-HT1A Receptor Function Makes Wound Healing a Happier Process.
Not available
S-EPMC6297675 | biostudies-literature
UnknownInterplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders.
Not available
S-EPMC6493079 | biostudies-literature
UnknownSerotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.
Not available
S-EPMC4047678 | biostudies-literature
UnknownMechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor.
Not available
S-EPMC4957245 | biostudies-literature
UnknownThe Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition.
Not available
S-EPMC4922583 | biostudies-literature
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