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TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
ProteomicsChanges in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma
Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-15 | PXD046360 | Pride
Tmt Ovarian cancer Serous borderline tumor 
GenomicsIdentification of clinical and molecular features for recurrent serous borderline ovarian tumor
Identification of clinical and molecular features for recurrent serous borderline ovarian tumor
PRJNA787481 | ENA
TranscriptomicsGenomic analysis of low-grade serous ovarian carcinomas [EXP]
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56443 | biostudies-arrayexpress
TranscriptomicsMolecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes
Epithelial ovarian cancer is morphologically and clinically heterogeneous. Transcriptional profiling has revealed molecular subtypes (referred to as M-bM-^@M-^\C-signaturesM-bM-^@M-^]) that correlate to biological as well as clinical features. We aimed to determine gene expression differences betwee...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-57477 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of low-grade serous ovarian carcinomas [IL610Q]
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-57279 | biostudies-arrayexpress
TranscriptomicsThe DNA methylomes of serous borderline tumours reveal subgroups with malignant-like or benign-like profiles
Serous borderline tumours (SBOT) are a challenging group of ovarian tumours positioned between benign and malignant disease. We have profiled the DNA methylomes of 12 low grade serous carcinoma (LGSC), 19 SBOT and 16 benign serous tumours (BST) across 27,578 CpG sites to further characterise the epi...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40105 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of low-grade serous ovarian carcinomas [ILOE]
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-57270 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human LMP ovarian tumors and low-grade ovarian carcinomas to identify genes which dffer from high-grade ovarian carcinomas - PAX2: a potential biomarker for low malignant potential ovarian tumors and low-grade serous ovarian carcinomas
Objective: Ovarian tumors of low-malignant potential (LMP) and low-grade serous ovarian carcinomas are thought to represent different stages on a tumorigenic continuum and to develop along pathways distinct from that of high-grade serous ovarian carcinoma. Past studies have utilized gene expression...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-14001 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of low-grade serous ovarian carcinomas [ILOEF]
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-57276 | biostudies-arrayexpress
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