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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
GenomicsA serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation [Timecourse]
A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation [Timecourse]
PRJNA724678 | ENA
GenomicsSerum starvation induces quiescence in ovarian cancer
Serum starvation induces quiescence in ovarian cancer
PRJNA1130989 | ENA
TranscriptomicsTranscription profiling of human cell types after 24 hrs serum starvation
Comparison of cell types after 24 hrs serum starvation.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-519 | biostudies-arrayexpress
GenomicsHuman microRNA (miRNA) expression during serum starvation
The study aimed to identify the differentially regulated microRNAs during serum starvation. We identified miRNAs exhibiting altered expression in asynchronous, serum starved and serum re-supplemented human cells. We identified several miRNAs that were upregulated following serum starvation and downr...
ORGANISM(S): Betapolyomavirus hominis Human alphaherpesvirus 2 Human betaherpesvirus 6B Merkel cell polyomavirus Homo sapiens Human alphaherpesvirus 1 Macacine alphaherpesvirus 1 Human betaherpesvirus 5 Human immunodeficiency virus 1 human gammaherpesvirus 4 Herpesvirus saimiri (strain 11) JC polyomavirus Human gammaherpesvirus 8 Betapolyomavirus macacae 
2017-09-05 | GSE103436 | GEO
TranscriptomicsIMR90 Quiescence
Transcription profiling from human primary fibroblasts grown either in the presence of serum (15% FBS) or arrested after serum starvation (0% FBS).
ORGANISM(S): Homo sapiens 
2014-06-17 | E-MTAB-2105 | biostudies-arrayexpress
GenomicsA serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation [SF_Diff]
A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation [SF_Diff]
PRJNA724677 | ENA
TranscriptomicsMicroRNA analysis during serum starvation of primary Human Foreskin Fibroblast cells
We used microRNA microarrays (Affy miRNA 2.0 array) to compare the miRNA expression between proliferating (mock) and different time points (12, 48, 72 hours) of serum starvation (to induce quiescence) in Human Foreskin Fibroblast (HFF) cells.
ORGANISM(S): Homo sapiens 
2017-06-01 | E-MTAB-2760 | biostudies-arrayexpress
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