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TranscriptomicsRestriction of LINE1 activity by RNAi correlates with mouse ES cell differentiation
Long interspersed elements 1 (LINE-1 or L1) are retrotransposons that dominate the mouse genomic landscape, and are expressed in Embryonic Stem Cells (ESCs), germ cells, and during early development. Based on clear precedents in plants and fission yeast, we investigated in this study a role for RNAi...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-43110 | biostudies-arrayexpress
TranscriptomicsCombinatorial flexibility of cytokine during Human T helper cells differentiation
Transcriptional analysis of human T cells differentiated in 4 T Helper context ( Th0, Th1, Th2 and Th17) in the presence or not of Interferon alpha We analyzed the transcriptomic profiles of 4 human naives T cells diferentiated in Th0, Th1, Th2 and Th17 in the presence or not of Interferon Alpha. Mi...
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-54627 | biostudies-arrayexpress
TranscriptomicsDeep-sequencing influences the results obtained in small-RNA sequencing
This study presents a comparison of small RNA sequencing libraries generated from the same cell lines but using different sequencing platforms and protocols. The samples were analyzed and compared at the level of miRNAs expression and as a population of small RNAs derived from repetitive elements. D...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-35368 | biostudies-arrayexpress
TranscriptomicsThe developmental dynamics and disease potential of random monoallelic gene expression
X-chromosome inactivation (XCI) in females and allelic exclusion of olfactory receptor or immunoglobulin loci, represent classic examples of random monoallelic expression (RME). RME of some single copy genes has also been reported, but the in vivo relevance of this remains unclear. Here we identify ...
ORGANISM(S): Mus musculus 
2014-02-27 | E-GEOD-54016 | biostudies-arrayexpress
GenomicsJarid2 methylation is required for PRC2 functioning during ES cells differentiation
We report that Jarid2 is methylated at K116 by the polycomb complex PRC2. We analyzed Jarid2 versus Methylated Jarid2 genomic localization by ChIP-seq. We also study H3K27 enrichment in Jarid2 knock out ES cells and in cells rescued for Jarid2 or a mutant that cannot be methylated. ChIP-seq for H3K2...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-55630 | biostudies-arrayexpress
TranscriptomicsATAC-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15871 | biostudies-arrayexpress
TranscriptomicsRNA-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15856 | biostudies-arrayexpress
UnknownMechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas.
Not available
S-EPMC6966520 | biostudies-literature
UnknownPatient Derived Xenografts (PDX) Models as an Avatar to Assess Personalized Therapy Options in Uveal Melanoma: A Feasibility Study.
Not available
S-EPMC10604955 | biostudies-literature
UnknownHuman papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma.
Not available
S-EPMC9394244 | biostudies-literature
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