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ProteomicsHypoxia-Induced Regulation of the Proteome in Multiple Myeloma Cell Lines
Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1-6% O2), known as hypoxia. For MM cells, hypoxia is a physiologic featur...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD030239 | Pride
Human Multiple myeloma Plasma cells Hypoxia Lc-ms/ms 
UnknownFunctional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1).
Not available
S-EPMC1828886 | biostudies-literature
TranscriptomicsChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...
ORGANISM(S): Homo sapiens 
2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
ProteomicsMYC as a Key Regulator of Protein Synthesis: Characterization of Downstream Targets in Multiple Myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder and frequently characterized by the 16 dysregulation of the MYC oncogene, which is associated with poor prognosis and disease progression. While MYC's involvement in transcriptional regulation is well-established, the functional role of MYC t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-15 | MSV000092169 | MassIVE
UnknownPolythiacalixarene-Embedded Gold Nanoparticles for Visible-Light-Driven Photocatalytic CO2 Reduction.
Not available
S-EPMC9284511 | biostudies-literature
UnknownUnderlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Not available
S-EPMC7275779 | biostudies-literature
UnknownGeneral lack of structural characterization of chemically synthesized long peptides.
Not available
S-EPMC6459998 | biostudies-literature
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
TranscriptomicsWhole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30442 | biostudies-arrayexpress
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