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GenomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner [SELEX]
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2014-06-06 | E-GEOD-58034 | biostudies-arrayexpress
TranscriptomicsSynergistic Repression of Embryonic Program by SET DOMAIN GROUP 8 and EMBRYONIC FLOWER 2 in Arabidopsis Seedlings
The seed maturation program occurs only during late phase of embryo development and repression of the maturation genes is pivotal for seedling development. However, mechanisms that repress the expression of this program in vegetative tissues are not well understood. A genetic screen was performed fo...
ORGANISM(S): Arabidopsis thaliana 
2011-12-31 | E-GEOD-29771 | biostudies-arrayexpress
TranscriptomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2013-08-26 | E-GEOD-39405 | biostudies-arrayexpress
TranscriptomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner [RNA-Seq]
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2014-06-06 | E-GEOD-58029 | biostudies-arrayexpress
TranscriptomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner [ChIP-chip]
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2014-06-06 | E-GEOD-58030 | biostudies-arrayexpress
GenomicsA SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
PRJNA1234167 | ENA
ProteomicsA SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
Epigenetic information can be inherited through a process known as transgenerational epigenetic inheritance (TEI). TEI can be initiated and maintained by small RNAs and histone modifications. The latter includes histone methylation, deposited by proteins with methyltransferase activity, including SE...
ORGANISM(S): Caenorhabditis elegans 
2025-03-11 | PXD057349 | Pride
Lc-ms/ms 
GenomicsPutative SET Domain-Containing Proteins Play Significant Roles in Regulating Sporulation, and Pathogenicity in Phytophthora capsici
Putative SET Domain-Containing Proteins Play Significant Roles in Regulating Sporulation, and Pathogenicity in Phytophthora capsici
PRJNA1244880 | ENA
ProteomicsInactivation of the nuclear interacting SET domain protein 1 (NSD1) impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
Nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We found that NSD1 knockdown altered erythroid clonogenic growth of human CD34+ hematopoietic cells. Ablation of Nsd1 in the hematopoietic system induced a transplantable erythroleu...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-08 | PXD017657 | Pride
Nsd1-erythroid differentiation-leukemia-gata1-ski 
GenomicNAB2-STAT6 Gene Fusions in Solitary Fibrous Tumor by Integrative Sequencing

Transcriptome sequencing of solitary fibrous tumors / hemangiopericytomas from a variety of anatomic sites revealed recurrent gene fusions between two genes, NAB2 and STAT6. All SFTs examined exhibited an in-frame fusion transcript encoding a fusion protein containing the EGR1 interaction domain ...

phs000567 | dbGaP
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