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MetabolomicsThe oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity
Cancer cells frequently reprogram one-carbon metabolic pathways to fulfill their vigorous demands of biosynthesis and antioxidant defense for survival and proliferation. Dysfunction of oncogenes or tumor suppressor genes is critically involved in this process, but the precise mechanisms by which can...
2025-04-22 | MTBLS11711 | MetaboLights
TranscriptomicsShort RNAs expression profiling in SET2 cells.
We report the application of Illumina short RNA sequencing for characterization and discovery of miRNAs and moRNAs in SET2 cells carrying JAK2 V617F mutation. Short RNAs sequencing for miRNA quantification, discovery and characterisation.
ORGANISM(S): Homo sapiens 
2012-02-08 | E-GEOD-30672 | biostudies-arrayexpress
TranscriptomicsInhibition of Jak2 in SET2 cell line with INC424 (two time points and 3 dose levels in triplicate)
SET2 cells were incubated with increasing concentration of INC424/Ruxolitinib for 3-6 h and RNA was purified. Affymetrix Genechip miRNA array 2.0 was used to identify miRNA species showing a differential expression in treated cells compared with control cells. Exponentially growing SET2 cells were c...
ORGANISM(S): Homo sapiens 
2012-02-08 | E-GEOD-33809 | biostudies-arrayexpress
ProteomicsRegulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 – HDX-MS dataset
Histone H3 lysine 36 methylation is a conserved histone modification that is critical for maintaining eukaryotic transcriptional fidelity and genomic stability. In yeast, this modification is catalyzed by Set2, an ortholog of the mammalian H3K36 methyltransferase SETD2. Previous genetic, biochemical...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-08-31 | PXD078353 | Pride
Structural proteomic Histone h3k36 methyltransferase set2 Hdx-ms 
Transcriptomicsset2 buratowski lab
H3K36 methylation by Set2 targets Rpd3S histone deacetylase to 3’ transcribed regions, repressing internal cryptic promoters and slowing elongation. To further explore the function of this pathway, global transcription was analyzed in yeast experiencing a series of carbon source shifts. Many pr...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-25 | E-MTAB-4268 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of SET-2 deletion and wild type yeast on sense and anti-sense arrays
The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic transcription initiation at certain genes. Here, using a genome-wide approach, we r...
ORGANISM(S): Saccharomyces cerevisiae 
2009-03-03 | E-TABM-265 | biostudies-arrayexpress
GenomicsSacharomyces cerevisiae Transcript Isoform mapping (set2)
Sacharomyces cerevisiae Transcript Isoform mapping (set2)
PRJNA488283 | ENA
UnknownNucleosome and ubiquitin position Set2 to methylate H3K36.
Not available
S-EPMC6706414 | biostudies-literature
GenomicsQuantitative analysis of wild type and set2 mutant transcriptomes
Quantitative analysis of wild type and set2 mutant transcriptomes
PRJNA805230 | ENA
GenomicsA conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation
A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation
PRJNA479784 | ENA
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