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ProteomicsGFAP and MBP peptides in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells and is upregulated in astrogliosis following traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown p...
ORGANISM(S): Homo Sapiens 
2022-07-18 | PXD026550 | panorama
ProteomicsProtein Profile Changes in the Frontotemporal Lobes in Human Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a serious public health issue with high morbidity and mortality rates. Previous proteomic studies on sTBI have mainly focused on human cerebrospinal fluid and serum, as well as on brain protein changes in murine models. However, human proteomic data in sTBI br...
ORGANISM(S): Homo sapiens (Human) 
2016-04-15 | PXD002783 | Pride
Severe traumatic brain injury  tmt (tandem mass tags)  human  proteomics 
ProteomicsProteomics characterization of the neuroprotective effects of low-dose methamphetamine on rats with traumatic brain injury (TBI)
Traumatic brain injury (TBI) causes hospitalizations and mortality worldwide with no approved neuroprotective treatments available, partly due to a poor understanding of the molecular mechanisms underlying TBI neuropathology and neuroprotection. We previously reported that the administration of low-...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-02 | PXD024317 | Pride
Ionstar Large-scale proteomics Traumatic brain injury Methamphetamine 
ProteomicsQuantitative Proteomics Reveals the Dynamic Pathophysiology across Different Stages in a Rat Model of Severe Traumatic Brain Injury
Background: Severe Traumatic Brain Injury (TBI) has become a growing health problem, causing a vast society burden worldwide. However, characteristic mechanisms between acute and subacute stages have not been systemically revealed. Methods: Sixty rats were randomly divided into sham surgery and mode...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-07 | PXD029312 | Pride
Acute phase Severe traumatic brain injury Subacute phase Characteristic mechanisms Quantitative proteomic Tandem mass tag-based 
ProteomicsTemporal proteomics of human cerebrospinal fluid reveals novel differentially-regulated proteins after severe traumatic brain injury
The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully elucidate changes in molecular pathways. Cerebrospinal fluid (CSF) provides a rich repository of brain-associated proteins that may be affected by TBI. Here, we implemented high-resolution mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035289 | Pride
Cerebrospinal fluid Secondary injury Inflammation Tbi Proteins Biomarker 
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
TranscriptomicsmiRNA expression of whole hippocampus 24hr post-injury in rat
Traumatic brain injury dysregulates microRNA expression in the brain. We hypothesized that injury-induced epigenetic changes contribute to neurodegeneration and learning and memory deficits after TBI. These changes may provide a mechanistic explanation for neuropsychiatric comorbidities in TBI patie...
ORGANISM(S): Rattus norvegicus 
2015-01-08 | E-GEOD-59646 | biostudies-arrayexpress
TranscriptomicsGene expression of whole hippocampus 24hr post-injury in rat
Traumatic brain injury (TBI) alters and dysregulates the expression of thousands of genes in the brain. Since some of the most common problems in TBI patients are learning and memory deficits, we are studying the effects of TBI on the hippocampus, a region of the brain which is essential for learnin...
ORGANISM(S): Rattus norvegicus 
2015-01-08 | E-GEOD-59645 | biostudies-arrayexpress
MetabolomicsTargeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury

Background: After spinal cord injury (SCI), lipid metabolism dysregulation at the lesion site exacerbates secondary damage. The transcription factor pu.1 has been implicated as a negative regulator of multiple lipid metabolism-related genes and pathways. However, its role in post-SCI lipid metabo...

2024-08-08 | MTBLS10453 | MetaboLights
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress
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