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MetabolomicsA gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI

A gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI


Probiotic L. reuteri attenuates neuroinflammation and anxiety symptoms through gut-brain axis via a novel metabolite 20-HETE in blast-induced traumatic brain injury

2026-07-17 | MTBLS15072 | MetaboLights
TranscriptomicsTranscriptome profiling in the DA and PVG inbred rat strains after traumatic brain injury
Genetic factors are believed to be of importance for outcome of traumatic brain injury (TBI). However, so far mainly allelic variation in apolipoprotein E4 has been studied in human TBI. In order to study the role of genetic factors in experimental TBI, we examined parental DA and PVG strains before...
ORGANISM(S): Rattus norvegicus 
2012-09-06 | E-MTAB-795 | biostudies-arrayexpress
UnknownRelationship between transdiagnostic dimensions of psychopathology and traumatic brain injury (TBI): A TRACK-TBI study.
Not available
S-EPMC8552293 | biostudies-literature
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD010602 | Pride
Ad Hippocampus Tmt Plasma Cortex Tbi 
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models II
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD010664 | Pride
Alzheimer’s disease Proteomics Htau Ps1/app Mild-tbi Brain profiles Plasma biomarker 
GenomicsTBI- soil microbiome
TBI- soil mycobiome Raw sequence reads
PRJNA1260755 | ENA
TranscriptomicsChanges in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
Warfare has long been associated with traumatic brain injury (TBI) in militarized zones. Common forms of TBI can be caused by a physical insult to the head-brain or by the effects of a high velocity blast shock wave generated by the detonation of an explosive device. While both forms of trauma are d...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
ProteomicsProteomics characterization of the neuroprotective effects of low-dose methamphetamine on rats with traumatic brain injury (TBI)
Traumatic brain injury (TBI) causes hospitalizations and mortality worldwide with no approved neuroprotective treatments available, partly due to a poor understanding of the molecular mechanisms underlying TBI neuropathology and neuroprotection. We previously reported that the administration of low-...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-02 | PXD024317 | Pride
Ionstar Large-scale proteomics Traumatic brain injury Methamphetamine 
GenomicsTimecourse RNAseq for Drosophila TBI
Timecourse RNAseq for Drosophila TBI
PRJNA718601 | ENA
ProteomicsHuman Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI
Traumatic brain injury (TBI) is a major cause of long-term neurological impairment, with aging amplifying vulnerability and worsening recovery. Older individuals face greater cognitive and motor deficits post-TBI and respond less effectively to treatments, as both aging and TBI independently elevate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD067584 | Pride
Tbi  aged  small extracellular vesicles (sevs)  human adipose derived stem cells (hasc)  microglia  astrocytes  neuroinflammation 
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