Sexual commitment

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protozoa (47)

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Transcription profiling by array (182)
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State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China (1)

Location

Iran (1)

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AP2X-1 is a negative regulator of Toxoplasma gondii sexual commitment

Toxoplasma gondii is a widespread protozoan with a complex life cycle, characterized by transitions between various hosts and developmental stages, each tailored to a specific niche within its host. However, the regulatory mechanisms governing these life cycle transitions are not well understood. In...

ORGANISM(S): Toxoplasma gondii ME49

2025-06-29 | PXD065585 | Pride

Regulators of sexual commitment in Plasmodium falciparum

PRJNA666191 | ENA

Identification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum

For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6...

ORGANISM(S): Plasmodium falciparum

2014-10-16 | E-GEOD-62364 | biostudies-arrayexpress

Deconvolving the transcriptional signature of sexual commitment in Plasmodium falciparum

This dataset aimed to investigate the transcriptional pathways driving the switch from asexual to sexual stage development of Plasmodium falciparum starting from the initial transcriptional response to variation in environmental LysoPC levels. Two culture adapted P. falciparum strains: Pf2004 from W...

ORGANISM(S): Plasmodium falciparum 3D7

2026-07-21 | E-MTAB-14868 | biostudies-arrayexpress

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

Sexual reproduction of Toxoplasma gondii, which is restricted to the small intestine of felids, is sparsely documented in studies involving domestic cats, which also raises ethical concerns. Chromatin modifiers dictate the developmental fate of the parasite during its multistage life cycle, but thei...

ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH

2023-09-16 | PXD039400 | Pride

Merogony Toxoplasma gondii Sexual commitment Apetala Transcription factor Gene expression Nanolc-ms/ms Epigenetic Chromatin

AP2X-1 is a negative regulator of Toxoplasma gondii sexual commitment

PRJNA1047515 | ENA

Regulators of sexual commitment in Plasmodium falciparum

The aim of this study was to identify transcriptonal responses during sexual commitment of P. falciparum mutants unable to form gametocytes.

ORGANISM(S): Plasmodium falciparum

2020-09-29 | GSE158689 | GEO

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

PRJNA561145 | ENA

Deconvolving the transcriptional signature of sexual commitment in Plasmodium falciparum

PRJEB86648 | ENA

Protein signature of sexually committed malaria parasites

Sexual commitment is a crucial step in the life cycle of the human malaria parasite that allows for the formation of transmissible gametocyte stages. The process of sexual commitment is influenced by various factors and is also marked by the timely expression of a minimal set of molecular markers a...

ORGANISM(S): Plasmodium falciparum (isolate 3D7)

2026-02-16 | PXD059080 | Pride

Schizonts Human malaria Sexual commitment Plasmodium falciparum

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