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ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
ProteomicsMapping of phosphorylation sites on Sgk3 by LC-MS/MS
The phosphorylation profile of Sgk3 protein expressed either in Sf9 insect cells or HEK 293T human cells was assessed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026281 | Pride
Activation loop Phosphorylation Sgk3 Turn motif Hydrophobic motif 
ProteomicsCharacterization of SGK3-PROTAC1, a highly specific SGK3 kinase PROTAC degrader
SGK3 is a PX domain containing protein kinase activated at endosomes downstream of Class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer to Class 1 PI3K or Akt inhibitors, by substituting for loss of Akt and restor...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013779 | Pride
Protac Sgk3 Degradation 
ProteomicsIdentification of Syntaxin 7 and 12 as the first selective substrates for SGK3
Deregulation of the PI3K/Akt pathway is a common feature in many types of cancer. Recent data has demonstrated that prolonged inhibition of breast cancer cell lines with PI3K and Akt inhibitors leads to up-regulation and increased activity of the AGC kinase Serum and glucocorticoid activated kinase ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014561 | Pride
Phosphoprpteomis Stx7 and stx12 Sgk3 
ProteomicsCDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway
SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative proteomics data and pu...
ORGANISM(S): Mus Musculus 
PXD035187 |
GenomicsSGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis
SGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis
PRJNA1116801 | ENA
UnknownDesign and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader.
Not available
S-EPMC6757289 | biostudies-literature
GenomicsSGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis
Excessive glucocorticoid exposure is associated with significant metabolic side effects, partly attributed to the transcriptional regulation of adipogenesis by the Glucocorticoid receptor (GR). However, emerging evidence suggests the involvement of alternative pathways beyond GR activation, which ar...
ORGANISM(S): Mus musculus 
2025-07-15 | GSE268382 | GEO
UnknownIn vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Not available
S-EPMC8318898 | biostudies-literature
UnknownSGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.
Not available
S-EPMC4255362 | biostudies-literature
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