Sh-sy5y cell line

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Unknown (438)
Genomics (149)
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Organisms

Homo sapiens (129)
Aerococcus urinae NBRC 15544 = CCUG 36881 (42)
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human gammaherpesvirus 4 (1)
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Organisms

Homo sapiens (102)
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Repository

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biostudies-arrayexpress (71)
geo (58)
pride (42)
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Tissue

Cell culture (15)
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Neuroblast (1)
Neuroblast proliferation (1)
Neuroblastoma cell (1)
Neuron (1)
Neuron associated cell (1)
SH-SY5Y cell (1)
Schwann cell (1)

Disease

Neuroblastoma (11)
Parkinson's disease (2)
Disease free (1)
Hereditary spastic paraplegia (1)
Herpes simplex (1)

Technology Type

Mass Spectrometry (42)
Shotgun proteomics (27)
Bottom-up proteomics (6)
Data-dependent acquisition (5)
Data-independent acquisition (4)
Affinity purification coupled with mass spectrometry proteomics (3)
All-ion fragmentation (3)
Top-down proteomics (3)
Gel-based experiment (2)
NMR spectroscopy (1)
Mass spectrometry (1)
Mass spectrometry assay (1)
SWATH MS (1)

Instrument Platform

Illumina Genome Analyzer IIx (4)
NextSeq 500 (3)
HiSeq X Ten (2)
Illumina HiSeq 2500 (2)
Illumina NovaSeq 6000 (2)
NA (1)
Illumina HiSeq 1000 (1)
Illumina HiSeq 4000 (1)
Orbitrap Eclipse (1)
Q Exactive (1)
LTQ Velos (Thermo Scientific) (1)
Direct infusion MS - positive (1)
Bruker (1)

Publication Date

2023 (17)
2013 (17)
2021 (15)
2025 (12)
2009 (12)
2018 (11)
2024 (11)
2022 (10)
2015 (9)
2010 (9)
2020 (8)
2016 (8)
2012 (8)
2011 (8)
2026 (7)
2014 (7)
2019 (6)
2017 (4)

CHEBI ID

CHEBI:28398 (1)
CHEBI:139272 (1)
CHEBI:17917 (1)
CHEBI:15671 (1)
CHEBI:46793 (1)
CHEBI:27607 (1)
CHEBI:43433 (1)
CHEBI:50599 (1)
CHEBI:62207 (1)
CHEBI:30830 (1)
CHEBI:16628 (1)
CHEBI:36219 (1)
CHEBI:28315 (1)
CHEBI:41941 (1)
CHEBI:741548 (1)
CHEBI:30813 (1)
CHEBI:27856 (1)
CHEBI:18059 (1)
CHEBI:74903 (1)
CHEBI:16344 (1)
CHEBI:30751 (1)
CHEBI:17790 (1)
CHEBI:17170 (1)
CHEBI:15347 (1)
CHEBI:16236 (1)
CHEBI:30849 (1)
CHEBI:16870 (1)
CHEBI:15699 (1)
CHEBI:17505 (1)
CHEBI:30746 (1)

Metabolite Name

Miscellaneous sugar (1)
Pi-methyl-histidine (1)
Oxidised Glutathione (1)
4-hydroxybutyrate (1)
L-allysine (1)
3-hydroxyvalerate (1)
Miscellaneous lipid (1)
Butanone (1)
L-alloisoleucine (1)
Tartrate (1)
Sn-glycero-3-phosphocholine (1)
Adenosine diphosphate (1)
Adenosine triphosphate (1)
Caprate (1)
Isocaproate (1)
3-Phenylpropionate (1)
Polyethylene glycol (1)
Alpha-Lactose (1)
Thymol (1)
Galactitol (1)
3-aminoisobutyrate (1)
2-hydroxybutyrate (1)
3,4-Dihydroxybenzeneacetic acid (1)
L-carnitine (1)
L-fucose (1)
Trimethylamine N-oxide (1)
Ethylmalonate (1)
Creatine phosphate (1)
Benzoate (1)
Methanol (1)

First Public Date

2024 (17)
2021 (15)
2014 (15)
2022 (14)
2025 (10)
2019 (10)
2023 (8)
2020 (8)
2017 (8)
2016 (8)
2018 (6)
2013 (5)
2026 (4)
2015 (4)

Modification

4'-dihydroxyphenylalanine (1)

Study type

Transcription profiling by array (46)
RNA-seq of coding RNA (9)
ChIP-seq (5)
Genotyping by array (2)
ChIP-chip by tiling array (1)
ChIP-chip by array (1)
MicroRNA profiling by high throughput sequencing (1)
Bisulfite-seq (1)
DNA-seq (1)
Proteomic profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (61)
2023 (55)
2021 (50)
2025 (39)
2024 (37)
2020 (35)
2016 (34)
2019 (32)
2013 (26)
2018 (24)
2017 (22)
2014 (18)
2015 (16)
2012 (14)
2011 (13)
2009 (13)
2010 (9)
2026 (3)
2007 (2)
2004 (2)
2008 (1)
2005 (1)
2002 (1)
1999 (1)

Lab affiliation

Department of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. Instituto Politécnico Nacional 2508, CP 07360 Ciudad de México (CDMX), México. Tel.: +52 55 5747 3354 (2)
Department of Cell Biology, Harvard Medical School, USA (2)
Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany (2)
1. Department of Chemistry, Korea University, Seoul 02841, Republic of Korea 2. Center for Proteogenome Research, Korea University, Seoul 02841, Republic of Korea (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH The Netherlands Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands (1)
Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Japan (1)
Center for Functional Protein Assemblies, Technical University of Germany, Germany (1)
Centre for MND Research, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW Australia (1)
Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, and Santa Lucia IRCCS Foundation, Rome, Italy (1)
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, 10032 (1)
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA (1)
Department of Neuroscience, University of Florida (1)
Dipartimento di Scienze Chimiche, Farmaceutiche ed Agrarie, Università degli Studi di Ferrara (1)
Director, MaineHealth Institute for Research, Proteomics and Lipidomics Laboratory (1)
Director, Proteomics and Lipidomics Core Facility, Mainehealth (1)
Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa (1)
Harvard Medical School Cell Biology USA (1)
Harvard Medical School Department of Cell Biology 240 Longwood Ave. Boston, Massachusetts 02115, USA (1)
Harvard Medical School, Boston, MA (1)
Harvard University Chemistry and Chemical Biology Department (1)
Infectious Diseases Translational Research Programme (ID TRP): Department of Microbiology & Immunology: Yong Loo Lin School of Medicine: LSI Immunology Programme: National University of Singapore, Singapore. (1)
Institute for Biochemistry and Molecular Biology, University of Bonn, Bonn, Germany (1)
Institute for ophthalmic research University of Tuebingen (1)
Judith Sleeman PhD FRSB Lecturer in Developmental Cell Biology BSRC Complex School of Biology University of St Andrews KY16 9ST UK +44 (0)1334 463524 (1)
LMU München, Department of Chemistry. Institute for Chemical Epigenetics – Munich (ICEM) (1)
Neurogenetics Department The Cyprus Institute of Neurology and Genetics 2371 Nicosia Cyprus (1)
Neurotoxin Research Group, School of Life Sciences, The University of Technology Sydney, Ultimo, NSW 2007, Australia; kenneth.rodgers@uts.edu.au (K.J.R.) (1)
Novo Nordisk Foundation Center for Protein Research Faculty of Health & Medical Sciences University of Copenhagen Blegdamsvej 3B DK-2200 Copenhagen N Denmark (1)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark (1)
Proteome Dynamics, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin, Germany Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany (1)

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Transcription profiling of neuronal differentiation in two subtypes of SH-SY5Y

Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...

ORGANISM(S): Homo sapiens

2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress

Expression analysis of Pea3, Erm and Er81 overexpression in SH-SY5Y cell line

Investigation of whole genome gene expression level changes in SH-SY5Y cells transfected pCDNA3-Pea3, pCDNA3-Erm, and pCDNA3-Er81 cells compared to pCDNA3 transfected cells as a control.

ORGANISM(S): Homo sapiens

2020-10-28 | E-MTAB-8473 | biostudies-arrayexpress

Transcription profiling of human human neuroblastoma SH-SY5Y cells identifies molecular effectors of unconjugated bilirubin

This SuperSeries is composed of the following subset Series:; GSE16656: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblatoma SH-SY5Y cells: 24h; GSE16766: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neurobl...

ORGANISM(S): Homo sapiens

2009-12-02 | E-GEOD-16768 | biostudies-arrayexpress

Transcription profiling of human neuroblastoma SH-SY5Y cells: 4h identifies molecular effectors of unconjugated bilirubin

The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...

ORGANISM(S): Homo sapiens

2009-12-02 | E-GEOD-16767 | biostudies-arrayexpress

Transcription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin

ORGANISM(S): Homo sapiens

2009-11-29 | E-GEOD-16656 | biostudies-arrayexpress

Transcription profiling of human human neuroblastoma SH-SY5Y cells: 1h identifies molecular effectors of unconjugated bilirubin

ORGANISM(S): Homo sapiens

2009-11-29 | E-GEOD-16766 | biostudies-arrayexpress

Profiling neuroblastoma SH-SY5Y with Paraquat treatment

Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared w...

ORGANISM(S): Homo sapiens

2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress

Analysis of Elk-1-VP16 overexpression in SH-SY5Y cell line

Investigation of whole genome expression in SH-SY5Y cells transfected Elk-1-VP16 cells compared to pCDNA3 transfected cells as a control.

ORGANISM(S): Homo sapiens

2021-02-28 | E-MTAB-9938 | biostudies-arrayexpress

Expression analysis of Pea3 overexpression in SH-SY5Y cell line

Investigation of whole genome gene expression level changes in SH-SY5Y cells transfected Pea3-VP16 cells compared to pCDNA3 transfected cells as a control.

ORGANISM(S): Homo sapiens

2017-01-11 | E-MTAB-5324 | biostudies-arrayexpress

mRNA expression analysis of human neuroblastoma cell line SH-SY5Y treated with siCLN3 vs siCTL.

To investigate impact of CLN3 deficiency on cell signaling and metabolism, SH-SY5Y neuroblastoma cells were transiently transfected with CLN3 siRNA (siCLN3; n=3) or control siRNA (siCTL; n=3). Transcriptomes of siCTL and siCLN3 SH-SY5Y cells were determined using Affymetrix Human Genome U133 plus 2 ...

ORGANISM(S): Homo sapiens

2023-11-15 | E-MTAB-12435 | biostudies-arrayexpress

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