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MetabolomicsLoss of SPTSSA Impairs Mitochondrial Function and Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells
Sphingolipids are bioactive membrane and signaling lipids that not only shape cellular architecture but also orchestrate a network of interconnected metabolic pathways. Their core building blocks, sphingoid bases, are synthesized by the serine palmitoyltransferase (SPT) complex. At its core, the SPT...
2026-10-09 | MTBLS15875 | MetaboLights
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells identifies molecular effectors of unconjugated bilirubin
This SuperSeries is composed of the following subset Series:; GSE16656: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblatoma SH-SY5Y cells: 24h; GSE16766: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neurobl...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16768 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells: 1h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16766 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma SH-SY5Y cells: 4h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16767 | biostudies-arrayexpress
TranscriptomicsProfiling neuroblastoma SH-SY5Y with Paraquat treatment
Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared w...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
TranscriptomicsExpression analysis of Pea3, Erm and Er81 overexpression in SH-SY5Y cell line
Investigation of whole genome gene expression level changes in SH-SY5Y cells transfected pCDNA3-Pea3, pCDNA3-Erm, and pCDNA3-Er81 cells compared to pCDNA3 transfected cells as a control.
ORGANISM(S): Homo sapiens 
2020-10-28 | E-MTAB-8473 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression profiles in human neuroblastoma SH-SY5Y cells exposed to norephedrine
To reveal the molecular mechanism underling necrotic neuronal cell death caused by norephedrine, we examined alteration of gene expression profile during norephedrine exposure in human neuroblastoma SH-SY5Y cells. The alteration of gene expression during norephedrine exposure (3 mM, 0,2 and 6 hours)...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-67643 | biostudies-arrayexpress
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