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ProteomicsGlycolytic enzyme aldolase A is necessary for reelin mediated neurite growth and arborization
Reelin is a large, secreted glycoprotein that is best known as an essential molecule directing neocortical neuronal migration, but reelin serves an important functional role in regulating neurite outgrowth and arborization as well. Canonically, reelin signals through the lipoprotein receptors apolip...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD046667 | Pride
Lc-ms  proteomics  aldolase a  reelin  neurite growth 
ProteomicsTranscriptomic and proteomic analysis of osteogenesis imperfecta disease-specific induced pluripotent stem cells
Background: Osteogenesis imperfecta (OI) is a rare genetic bone disease that causes bone fragility and growth deformities. OI-derived disease-specific induced pluripotent stem cells (iPSC) can reflect disease pathogenesis. Hence, investigating the pathogenesis of OI through OI-iPSCs holds significan...
ORGANISM(S): Homo Sapiens 
2025-06-19 | PXD065237 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation
dNxf2 directly interacts with dNxf1 to compete with its binding to NPC
ORGANISM(S): Drosophila Melanogaster 
2019-08-01 | PXD014884 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
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