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ModelsShah2020 - Predicting Human Liver Microsomal Stability of small molecules
The Human Liver Microsomal assay takes into account the liver-mediated drug metabolism to assess the stability of a compound in the human body. The NIH-NCATS group took a proprietary dataset of 4300 compounds with its associated HLM (in vitro half-life; unstable ≤  30 min, stable >30 min) and used i...
2024-05-13 | MODEL2405130005 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ModelsShah2020 - Predicting liver cytosol stability of small molecules.
The human liver cytosol stability model is used for predicting the stability of a drug in the cytosol of human liver cells, which is beneficial for identifying potential drug candidates early during the drug discovery process. If a drug compound is quickly absorbed, it may not reach the intended tar...
2024-04-22 | MODEL2404220005 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
UnknownCardiovascular and Cerebrovascular Disease Mortality in Asian American Subgroups.
Not available
S-EPMC9117444 | biostudies-literature
ProteomicsKidney proteomics in the folic acid (FA) induced nephropathy mouse model
Treatments for kidney fibrosis represent an urgent yet unmet clinical need. Effective therapies are limited due to not well understood molecular pathogenesis. We aimed at generating a comprehensive and integrated multi-omics data set (RNA/ microRNA transcriptomics and proteomics) of fibrotic kidneys...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD011453 | Pride
Ckd Fibrosis Mouse Kidney 
ProteomicsKidney proteomics in the unilateral ureter obstruction (UUO) mouse model
Treatments for kidney fibrosis represent an urgent yet unmet clinical need. Effective therapies are limited due to not well understood molecular pathogenesis. We aimed at generating a comprehensive and integrated multi-omics data set (RNA/ microRNA transcriptomics and proteomics) of fibrotic kidneys...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD010861 | Pride
Ckd Fibrosis Mouse Kidney 
MetabolomicsGNPS - Bacterial Bile Acid Amidates (BBAAs) data set
Data acquired for conjugated bile acids with amino acids analysis of human fecal samples by targeted LC-MS. These samples are a part of a study investigating a new BSH function as an amine N-acyl transferase that conjugates amines to form bacterial bile acid amidates (BBAAs).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-18 | MSV000093144 | GNPS
UnknownRepurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
Not available
S-EPMC7727327 | biostudies-literature
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