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ProteomicsComprehensive Proteome Profiling of Cytochrome P450 Isoforms in Cancer Models
Cytochrome P450 (CYP450) enzymes are essential for drug metabolism, xenobiotic detoxification, and procarcinogen activation, playing a pivotal role in both normal physiology and cancer biology. Their expression varies significantly across tissues and tumour types, reflecting the metabolic heterogene...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-11-10 | PXD062999 | Pride
Cyp450 enzymes Personalized therapy Colorectal cancer Gel-lc-ms Head and neck cancer Biomarkers 
ProteomicsEVALUATION OF RESEARCH BIOPSIES IN KIDNEY TRANSPLANTATION
This study set out to investigate the optimal biopsy size required for adequate quality tissue for histological and proteome assessment while upholding patient safety which is of paramount concern.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-06 | PXD032354 | Pride
Kidney transplantation  punch biopsy  core needle biopsy  shotgun proteomics 
ProteomicsNovel mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer: A Proteomic Investigation
One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU), the most commonly used drug in CRC patients. Whilst some mechanisms of resistance are well-known, it is clear from the stasis i...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047672 | Pride
Colorectal cancer  drug resistance mechanisms  in vitro models  proteomics  5-fluorouracil  stable isotope labelling with amino acids in cell culture (silac) 
ProteomicsComparison of gel and urea methods of digestion for proteomic analysis of organ perfusion solutions
The aim of this study was to develop an optimized Shotgun proteomics method for perusate by comparing and identifying the most effective and reliable techniques for protein estimation and digestion.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040856 | Pride
Kidney Liver Proteomic Organ transplantation Perfusate 
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