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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
ProteomicsProteomics of REPLICANT Perfusate Detects Changes in the Metastatic Lymph Node Microenvironment
n breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently showed that patient-derived ALNs can be sustained ex-vivo using normothermic perfusion. We now compare reactive (tumour-free; n = 5) and macro...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD022722 | Pride
Lc-msms Tmt Cancer 
TranscriptomicsRNA-seq of the RNA cargo of extracellular vesicles released in perfusate and bile during ex situ isolated liver perfusion of porcine livers exposed to 60-minutes warm ischemia vs. control (no warm ischemia)
There is a ever widening gap between the availability of donor livers suitable for transplantation and liver transplant demand of a growing waiting list. To expand the pool of liver grafts, donation after circulatory death is increasingly being used. Livers procured after circulatory death are expos...
ORGANISM(S): Sus scrofa 
2024-09-27 | E-MTAB-11420 | biostudies-arrayexpress
UnknownProteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment.
Not available
S-EPMC7935848 | biostudies-literature
UnknownPerfusate hemoglobin during normothermic liver machine perfusion as biomarker of early allograft dysfunction: A pilot study.
Not available
S-EPMC11687207 | biostudies-literature
UnknownHemodynamics and Metabolic Parameters in Normothermic Kidney Preservation Are Linked With Donor Factors, Perfusate Cells, and Cytokines.
Not available
S-EPMC8784871 | biostudies-literature
GenomicsInflammatory gene expression in livers undergoing ex situ normothermic perfusion is attenuated by leukocyte removal from the perfusate
Inflammatory gene expression in livers undergoing ex situ normothermic perfusion is attenuated by leukocyte removal from the perfusate
PRJNA1030911 | ENA
GenomicsComparative Landscape of Small RNAs in Tissue and Liquid Biopsies for Liver Transplant Outcomes [Perfusate small RNAseq]
Comparative Landscape of Small RNAs in Tissue and Liquid Biopsies for Liver Transplant Outcomes [Perfusate small RNAseq]
PRJNA1368833 | ENA
UnknownQuantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion.
Not available
S-EPMC8945564 | biostudies-literature
UnknownAssociations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function.
Not available
S-EPMC4844819 | biostudies-literature
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