Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
ProteomicsMilking it? Assessing the degradation of ancient milk proteomes
The origins, prevalence and nature of dairying have been long debated by archaeologists. Within the last decade, new advances in high-resolution mass spectrometry have allowed for the direct detection of milk proteins from archaeological remains, including ceramics, dental calculus, and preserved da...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD022368 | Pride
Milk Authentication Palaeoproteomics Deamidation 
ProteomicsPalaeoproteomics of archaeological shell beads
In this project we have applied palaeoproteomics to study archaeological shell beads dating back to the beginning of the 7th mill. cal BCE and recovered from a prehistoric site in Jordan (Ba'ja). These beads were made of mollusc shells and were of unknown origin, but suspected to be made of larger b...
ORGANISM(S): Mollusca 
2024-11-04 | PXD041082 | Pride
Archaeological shells Mollusc shells Ancient proteins Palaeoproteomics Lc-ms/ms 
GenomicsThe Genomic Binding Sites of an Endogenous Non-Coding RNA
Long non-coding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed CHART, a hybridization-based technique that specifically enriches endogenous RNAs along with their targets from reversibly-crosslinked...
ORGANISM(S): Drosophila melanogaster 
2011-12-07 | E-GEOD-28180 | biostudies-arrayexpress
TranscriptomicsToxicogenomic Responses to Inorganic and Organic Mercury in Caenorhabditis elegans
Humans are exposed to both inorganic and organic mercury. While the toxicity of mercury is well established, much remains to be resolved about how different mercurials act at the molecular level. To address this issue, we employed a toxicogenomics approach using the nematode C. elegans. Using sub...
ORGANISM(S): Caenorhabditis elegans 
2013-09-09 | E-GEOD-28915 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Arabidopsis Scaffold/Matrix Attachment Regions Reveals Link to Nucleosome-Disfavoring Poly(dA:dT) Tracts
Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of distribution and genomic context of S/MARs is thought to be important for processes such as chromatin organization and modulation of gene expression. Despite the importance of such processes, much is unknown a...
ORGANISM(S): Arabidopsis thaliana 
2014-02-03 | E-GEOD-45549 | biostudies-arrayexpress
ProteomicsSuper-paramagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer growth
Tumor associated macrophages (TAMs) are known to play a role in a multitude of processes that facilitate lung cancer growth, including the suppression of tumoricidal immune activation and the absorption of chemotherapeutics. Therefore, deciphering new therapies to reprogram TAMs towards an anti-tumo...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-18 | PXD040145 | Pride
Macrophages Immunotherapy Spion Iron Lung cancer 
TranscriptomicsTranscriptional profiling in skin of K14Sin3KO mice
Expression analysis of K14Sin3afl/flCreER,K14Mycfl/flCreER and K14Sin3aMycfl/flCreER effects on gene expression in adult mouse skin. We used a conditional knock out strategy to delete Sin3a and/or c-Myc specifically in adult mouse K14 positive keratinocytes and analysed the resulting changes in gene...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-554 | biostudies-arrayexpress
ProteomicsGlobal profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry
Interaction proteomics studies have provided fundamental insights into multimeric biomolecular assemblies and cell-scale molecular networks. Significant recent developments in mass spectrometry-based interaction proteomics have been fueled by rapid advances in label-free, isotopic, and isobaric quan...
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD007132 | Pride
Transcription Dna-protein interactions Binding affinity Chromatin 
ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (XL-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056360 | Pride
Xl-ms Progesterone receptor Crosslinking 
Sort   by:  
 Page size