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TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [HELP]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35815 | biostudies-arrayexpress
GenomicsDNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
Changes in DNA methylation are required for the formation of germinal centers (GC), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated recently in DNA demethylation through its deaminase activity coupled with DNA repai...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-71702 | biostudies-arrayexpress
TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [RNA-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35838 | biostudies-arrayexpress
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in primary Diffuse Large B cell Lymphoma (DLBCL) and normal Germinal Center B Cells
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma with variable biology and clinical behavior. The current classification does not fully explain the biological and clinical heterogeneity of DLBCLs. In this study we carried out genome-wide DNA methylatio...
ORGANISM(S): Homo sapiens 
2014-01-18 | E-GEOD-54200 | biostudies-arrayexpress
TranscriptomicsAltered Epigenetic Regulation of Homeobox Genes in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the molecular changes during OSCC carcinogenesis, we performed unbiased, whole genome deep sequencing (RNA-seq) using RNA isolated from cultured, human TERT-immortalized, non-tumorigenic OKF6-TERT1R and OSCC SCC-9 cells. OKF6-TERT1R cells and SCC-9 cells were plated in 10 cm2 t...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51415 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression changes in mouse tongue squamous cell carcinomas induced by 4-nitroquinoline 1-oxide (4-NQO)
We hypothesized that the expression of many genes are dysregulated during oral cancer carcinogenesis. We examined genome-wide transcript levels in normal mouse tongues and the tongue squamous cell carcinomas induced by 4-NQO. The results will provide important information for the diagnosis, prevent...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54246 | biostudies-arrayexpress
TranscriptomicsChemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [methylation]
Silencing of genes that suppress the malignant phenotype by DNA methylation spurred an interest in the clinical use of epigenetic reprogramming agents. Single therapy is unlikely to be curative in the context of a heterogeneous disease such as Diffuse Large B cell Lymphomas (DLBCL). The combination ...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-31101 | biostudies-arrayexpress
TranscriptomicsRecruitment of FOXP1 to target genes in diffuse large B-cell lymphoma (DLBCL) cells
Identification of FOXP1 target genes in the OCI-Ly1 DLBCL cell line by ChIP-on-chip Three replicates of the FOXP1 ChIP-on-chip were performed in the OCI-Ly1 cells
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-44243 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
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