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ProteomicsUnbiased proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes highly relevant to autism spectrum disorder
Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome (PMS), autism spectrum disorders (ASDs) and intellectual disability (ID). Although a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizin...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-08 | PXD005192 | Pride
Shank3 mutants Proteomics Hippocampus Striatum Postsynaptic density (psd) 
UnknownMolecular Dynamics Simulations of Wild Type and Mutants of SAPAP in Complexed with Shank3.
Not available
S-EPMC6337207 | biostudies-literature
ProteomicsA Bidirectional Switch in the Shank3 Phosphorylation State Is Necessary to Enable Synaptic Scaling Up and Down
Wu C, Tatavarty V, Jean-Beltran PM, Guerrero A, Keshishian H, Krug K, MacMullan M, de Arce KP, Carr SA, Cottrell J, Turrigiano GG. 2021 Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of posttranslational modifications in th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-07-30 | MSV000087926 | MassIVE
UnknownShank3 modulates sleep and expression of circadian transcription factors.
Not available
S-EPMC6488297 | biostudies-literature
UnknownShank3 influences mammalian sleep development.
Not available
S-EPMC9588578 | biostudies-literature
UnknownAutism-like atypical face processing in <i>Shank3</i> mutant dogs.
Not available
S-EPMC11963970 | biostudies-literature
UnknownInhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation.
Not available
S-EPMC7483244 | biostudies-literature
UnknownThe Shank3-InsG3680(+/+) mouse model of autism spectrum disorder displays auditory avoidance in a novel behavioral test.
Not available
S-EPMC10483143 | biostudies-literature
UnknownImpaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs.
Not available
S-EPMC10829216 | biostudies-literature
UnknownAutism-associated gene shank3 is necessary for social contagion in zebrafish.
Not available
S-EPMC10311831 | biostudies-literature
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