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ProteomicsCPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells
Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059026 | Pride
Mff Stemness maintenance Cpt1a Ovarian cancer stem cells Mams 
ProteomicsCarnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
Mitochondria are dynamic organelles that are important for cell growth and proliferation. Dysregulated mitochondrial dynamics are highly associated with the initiation and progression of various cancers, including ovarian cancer. However, the regulatory mechanism underlying mitochondrial dynamics is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD041990 | Pride
Mitochondrial dynamics  mff  succinylation  ovarian cancer 
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